| Erythropoietin improves the postresuscitation myocardial dysfunction and survival in the asphyxia-induced cardiac arrest model. | |
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MedLine Citation:
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PMID: 17483742 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the effect of erythropoietin for the management of postresuscitation myocardial dysfunction following asphyxia-induced cardiac arrest. Male adult Wistar rats were used for the prospective controlled animal study. Asphyxia-induced cardiac arrest was performed by turning-off the ventilator and clamping the endotracheal tube. Cardiopulmonary resuscitation with an intravenous injection of 0.01 mg/kg epinephrine and mechanical ventilation were started after 6.5 minutes of asphyxia. The resuscitated animals received either erythropoietin (5000 U/kg) or equivalent volume of 0.9% saline as placebo intravenously 3 minutes after return of spontaneous circulation. The erythropoietin treatment produced better left ventricular dP/dt40 and -dP/dt in the invasive hemodynamic measurements, and left ventricular fraction shortening by echocardiography. Administration of erythropoietin also improved three days survival among those successfully resuscitated. The molecular effects of erythropoietin were shown by activation of its down streaming Akt and ERK 42/44 signaling pathways. EPO has the potential to improve postresuscitation myocardial dysfunction and short term survival in rats after asphyxia-induced cardiac arrest. |
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Authors:
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Chien-Hua Huang; Chiung-Yuan Hsu; Huei-Wen Chen; Min-Shan Tsai; Hsiao-Ju Cheng; Chia-Hua Chang; Yuan-Teh Lee; Wen-Jone Chen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: 28 ISSN: 1073-2322 ISO Abbreviation: Shock Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-18 Completed Date: 2007-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: United States |
Other Details:
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Languages: eng Pagination: 53-8 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, National Taiwan University Medical College and Hospital, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asphyxia / complications Cardiopulmonary Resuscitation / methods* Cardiotonic Agents / administration & dosage Disease Models, Animal Erythropoietin, Recombinant / administration & dosage* Heart / drug effects*, physiopathology Heart Arrest / drug therapy, etiology, physiopathology, therapy* Male Rats Rats, Wistar Signal Transduction / drug effects Ventricular Dysfunction, Left / drug therapy, etiology, physiopathology, therapy |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Erythropoietin, Recombinant |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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