Document Detail


Erythropoietin improves functional and histological outcome in neonatal stroke.
MedLine Citation:
PMID:  15879287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal stroke is a condition that leads to disability in later life, and as yet there is no effective treatment. Recently, erythropoietin (EPO) has been shown to be cytoprotective following brain injury and may promote neurogenesis. However, the effect of EPO on functional outcome and on morphologic changes in neonatal subventricular zone (SVZ) following experimental neonatal stroke has not been described. We used a transient focal model of neonatal stroke in P10 rat. Injury was documented by diffusion weighted MRI during occlusion. Immediately upon reperfusion, either EPO (5U/gm) or vehicle was administered intraperitoneally and animals were allowed to grow for 2 wk. Sensorimotor function was assessed using the cylinder rearing test and then brains were processed for volumetric analysis of the SVZ. Stroke induced SVZ expansion proportional to hemispheric volume loss. EPO treatment markedly preserved hemispheric volume and decreased the expansion of SVZ unilaterally. Furthermore, EPO treatment significantly improved the asymmetry of forelimb use following neonatal stroke. This functional improvement directly correlated with the amount of preserved hemispheric volume. These results suggest EPO may be a candidate in the treatment of neonatal stroke.
Authors:
Yun Sil Chang; Dezhi Mu; Michael Wendland; R Ann Sheldon; Zinaida S Vexler; Patrick S McQuillen; Donna M Ferriero
Related Documents :
7986287 - Brain lesions of fetal onset in encephalopathic infants with nonimmune hydrops fetalis.
15321957 - The scottish perinatal neuropathology study: clinicopathological correlation in early n...
7863937 - Development of posterior fossa dural sinuses, emissary veins, and jugular bulb: morphol...
3096107 - Cranial sonography of the occipital horns and gyral patterns in the occipital lobes.
25119107 - Risk factors and adverse perinatal outcomes among term and preterm infants born small-f...
10796197 - Fat supplementation of human milk for promoting growth in preterm infants.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-05-05
Journal Detail:
Title:  Pediatric research     Volume:  58     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-29     Completed Date:  2005-09-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  106-11     Citation Subset:  IM    
Affiliation:
Departments of Neurology and Pediatrics, University of California-San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143-0663, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Behavior, Animal
Brain / metabolism,  pathology
Brain Injuries / pathology
Coloring Agents / pharmacology
Diffusion
Erythropoietin / pharmacology,  physiology*
Erythropoietin, Recombinant / pharmacology
Hypoxia-Ischemia, Brain
Magnetic Resonance Imaging / methods
Neurons / metabolism
Oxazines / pharmacology
Rats
Rats, Sprague-Dawley
Reperfusion Injury
Stroke / pathology
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Coloring Agents; 0/Erythropoietin, Recombinant; 0/Oxazines; 11096-26-7/Erythropoietin; 18472-89-4/cresyl violet

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Phylogenetic analysis and description of Eperythrozoon coccoides, proposal to transfer to the genus ...
Next Document:  Changes in fetal lung distension alter expression of vascular endothelial growth factor and its isof...