Document Detail


Erythropoietin impairs endothelial vasodilatory function in patients with renal anemia and in healthy subjects.
MedLine Citation:
PMID:  16166804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIM: The mechanisms underlying the aggravation or development of hypertension frequently seen during treatment of renal anemia with epoetins are not fully elucidated. The aim of the present study was to investigate the effects of epoetin alfa on endothelial vasodilatory function in patients with renal anemia and in healthy subjects. METHODS: Eighteen preuremic patients with anemia (GFR 23.4 +/- 11 SD ml/min, Hb 101 +/- 8 g/l) and 10 healthy subjects underwent evaluation of endothelium-dependent vasodilation (EDV) and endothelium-independent vasodilation (EIDV) by means of forearm blood flow (FBF) measurements with venous occlusion plethysmography during local intra-arterial infusions of methacholine (MCh, evaluating EDV) and sodium nitroprusside (SNP, evaluating EIDV). These investigations were performed before and 30 min after an intravenous injection of epoetin alfa (10,000 IU). Ten healthy subjects underwent the same procedure with the exception that saline were given instead of epoetin. The patients were treated with epoetin alfa subcutaneously for 12-19 weeks and reevaluated when Hb exceeded 120 g/l. RESULTS: EDV was attenuated after the epoetin injection in both renal patients and healthy subjects. This impairment persisted after anemia had been treated. EDIV and blood pressure remained constant. Saline had no effect on the variables measured. CONCLUSION: Our results indicate that epoetin alfa impairs endothelial function in renal patients and healthy subjects which may have an impact on vascular complications.
Authors:
Margus Annuk; Torbjörn Linde; Lars Lind; Bengt Fellström
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-15
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  102     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2006  
Date Detail:
Created Date:  2006-01-06     Completed Date:  2006-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c30-4     Citation Subset:  IM    
Copyright Information:
2006 S. Karger AG, Basel.
Affiliation:
Department of Medical Sciences, University Hospital, Uppsala, Sweden. Margus.Annuk@medsci.uu.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / drug therapy*
Blood Pressure / drug effects
Endothelium, Vascular / physiopathology*
Epoetin Alfa / administration & dosage,  pharmacology*
Erythropoietin
Female
Forearm / physiology
Hematinics / administration & dosage,  pharmacology*
Humans
Injections, Intravenous
Male
Regional Blood Flow
Vasodilation / drug effects
Chemical
Reg. No./Substance:
0/Hematinics; 11096-26-7/Erythropoietin; 113427-24-0/Epoetin Alfa

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