| Erythropoietin (epoetin) as a protective factor for the brain. | |
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MedLine Citation:
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PMID: 15191705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Erythropoietin (EPO) has been viewed traditionally as a hematopoietic cytokine. Emerging evidence now exists supporting a physiologic role for EPO within the nervous system. EPO is expressed in the developing central nervous system and is capable of regulating the production of neuronal progenitor cells. There are numerous preclinical studies demonstrating a neuroprotective potential for EPO in a variety of disorders of both the central and peripheral nervous systems. A small pilot study in patients with acute ischemic stroke has recently been completed and the results are encouraging. Its mechanism of action is multifactorial but probably related to its ability to act as an antiapoptotic agent. Its widespread use clinically for the treatment of anemias has given us the experience and knowledge of its safety and pharmacokinetics. EPO is thus an ideal compound to study for the potential treatment of a variety of neurologic disorders. |
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Authors:
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Samit Malhotra; Sheetal Nijhawan; Daniel M Rosenbaum |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current atherosclerosis reports Volume: 6 ISSN: 1523-3804 ISO Abbreviation: Curr Atheroscler Rep Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-11 Completed Date: 2004-11-06 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: United States |
Other Details:
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Languages: eng Pagination: 301-6 Citation Subset: IM |
Affiliation:
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Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, KC-303, Bronx, NY 10461, USA. drosenba@aecom.yu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects*, metabolism, physiopathology Epoetin Alfa / physiology, therapeutic use Erythropoietin, Recombinant / physiology*, therapeutic use* Hematinics / therapeutic use* Humans Nervous System Diseases / drug therapy, metabolism, physiopathology Neuroprotective Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Erythropoietin, Recombinant; 0/Hematinics; 0/Neuroprotective Agents; 113427-24-0/Epoetin Alfa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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