| Erythropoietin enhances neurological recovery after experimental spinal cord injury. | |
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MedLine Citation:
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PMID: 16477096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Erythropoietin is a hematopoietic growth factor. It is also involved in neurodevelopment and neuroprotection. The purpose of this study was to evaluate the effectiveness of erythropoietin in enhancing the neurological recovery following experimental spinal cord injury. METHODS: Rats were randomly divided into 4 groups. Group 1 received only laminectomy. Group 2, 3, and 4 have undergone a spinal contusion injury of 50 gr/cm. Group 2 received no medication. Group 3 received 30 mg/kg methylprednisolone. Group 4 received 5000 IU/kg recombinant human erythropoietin. Following injury, neurological recovery was evaluated for 14 days, using a swimming test. RESULTS: At day 1, there was no difference between mean motor scores of group 2, 3, and 4. Following day 1, rats in group 4 exhibited a marked improvement in motor score, and this was maintained throughout the study. When compared to group 2, mean motor score of group 4 was significantly higher at day 4, 7, 10, and 14. When compared to group 3, mean motor score of group 4 was significantly higher at day 7, 10, and 14. CONCLUSION: These findings suggest that erythropoietin enhances neurological recovery following spinal cord injury and it seems to be more effective than methylprednisolone at the given doses. |
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Authors:
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Burak O Boran; Ahmet Colak; Murat Kutlay |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Restorative neurology and neuroscience Volume: 23 ISSN: 0922-6028 ISO Abbreviation: Restor. Neurol. Neurosci. Publication Date: 2005 |
Date Detail:
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Created Date: 2006-02-14 Completed Date: 2006-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9005499 Medline TA: Restor Neurol Neurosci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 341-5 Citation Subset: IM |
Affiliation:
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Anadolu Cinar Hospital, Istanbul, Turkey. burakoboran@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal* Erythropoietin, Recombinant / therapeutic use* Humans Male Methylprednisolone / therapeutic use Motor Activity / drug effects Neurologic Examination Neuroprotective Agents / therapeutic use* Rats Rats, Wistar Recovery of Function / drug effects* Spinal Cord Injuries / drug therapy* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Erythropoietin, Recombinant; 0/Neuroprotective Agents; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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