| Erythropoietin as a novel brain and kidney protective agent. | |
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MedLine Citation:
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PMID: 21675055 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Erythropoietin is a 30.4 kDa glycoprotein produced by the kidney, which is mostly known for its physiological function in regulating red blood cell production in the bone marrow Accumulating evidence, however suggests that erythropoietin has additional organ protective effects, which may specifically be useful in protecting the brain and kidneys from injury. Experimental evidence suggests that these protective mechanisms are multi-factorial in nature and may include inhibition of apoptotic cell death, stimulation of cellular regeneration, inhibition of deleterious pathways and promotion of recovery. In this article we review the physiology of erythropoietin, assess previous work that supports the role of erythropoietin as a general tissue protective agent and explain the mechanisms by which it may achieve this tissue protective effect. We then focus on specific laboratory and clinical data that suggest that erythropoietin has a strong brain protective and kidney protective effect. In addition, we comment on the implications of these studies for clinicians at the bedside and for researchers designing controlled trials to further elucidate the true clinical utility of erythropoietin as a neuroprotective and nephroprotective agent. Finally, we describe EPO-TBI, a double-blinded multi-centre randomised controlled trial involving the authors that is being conducted to investigate the organ protective effects of erythropoietin on the brain, and also assesses its effect on the kidneys. |
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Authors:
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E M Moore; R Bellomo; A D Nichol |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anaesthesia and intensive care Volume: 39 ISSN: 0310-057X ISO Abbreviation: Anaesth Intensive Care Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-06-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0342017 Medline TA: Anaesth Intensive Care Country: Australia |
Other Details:
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Languages: eng Pagination: 356-72 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Preventive Medicine, Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00987454 |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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