Document Detail


Erythropoietic response to endogenous erythropoietin in premature very low birth weight infants.
MedLine Citation:
PMID:  19808699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite the common occurrence of anemia in very low birth weight (VLBW) infants, the erythropoiesis and Hb production rates and their relationship to plasma erythropoietin (EPO) concentrations remain unknown in these subjects. To determine these quantities, all blood removed by phlebotomy and administered by red blood cell (RBC) transfusion over the first 30 days of life was recorded in 14 ventilated VLBW infants born at 24 to 28 weeks of gestation. Discarded blood from frequent clinically ordered laboratory blood samples was used to construct plasma EPO, Hb, and RBC concentration-time profiles for each infant. A pharmacodynamic Hb mass balance model that accounted for the dynamic hematological conditions experienced by these infants was simultaneously fitted to the plasma EPO, Hb, and RBC concentrations from each individual subject, while accounting for subject growth. Based on the model estimates, an average of 4.69 g of Hb was produced over the first 30 days of life, compared with 5.97 g removed by phlebotomies and 12.3 g administered by transfusions. These high transfusion amounts were consistent with a relatively short RBC life span and rapidly expanding blood volume with infant growth. The estimated mean body weight-scaled Hb production rate dropped nearly 3-fold after birth to 0.144 g/day x (kg)(3/4). Although only estimated in a subset of the subjects, the mean plasma EPO EC(50) of 28.5 mU/ml and maximal Hb production rate (E(max)) indicated that a severalfold increase in Hb production rate could be achieved with only a modest increase in plasma EPO concentrations.
Authors:
Kevin J Freise; John A Widness; Peter Veng-Pedersen
Related Documents :
21705959 - Long-chain polyunsaturated fatty acid supplementation in infancy reduces heart rate and...
10657829 - Changing practices of red blood cell transfusions in infants with birth weights less th...
18616629 - Intravenous immune globulin reduces the need for exchange transfusions in rhesus and ab...
9395429 - Nutritional benefits of neonatal screening for cystic fibrosis. wisconsin cystic fibros...
21540319 - Utility of the national death index in ascertaining mortality in acquired immunodeficie...
21082539 - Type and timing of ventilation in the first postnatal week is associated with bronchopu...
15971389 - Chest radiograph screening for tuberculosis in a hong kong prison.
10437939 - The reference range of cd4+ and cd8+ t-lymphocytes in healthy non-infected infants born...
8446079 - Implementation of a quiet hour: effect on noise levels and infant sleep states.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-10-06
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  332     ISSN:  1521-0103     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-21     Completed Date:  2010-01-26     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-37     Citation Subset:  IM    
Affiliation:
Division of Pharmaceutics, College of Pharmacy , The University of Iowa, Iowa City, IA 52242, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Birth Weight
Erythrocyte Transfusion
Erythropoiesis / physiology*
Erythropoietin / blood*
Female
Gestational Age
Hemoglobins / analysis*
Humans
Infant, Newborn
Infant, Premature / blood*
Infant, Very Low Birth Weight / blood*
Male
Models, Biological
Phlebotomy
Respiration, Artificial
Grant Support
ID/Acronym/Agency:
2 P01-HL046925-11A1/HL/NHLBI NIH HHS; P01 HL046925/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins; 11096-26-7/Erythropoietin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD...
Next Document:  Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression...