Document Detail


Erythropoietic adaptations to endurance training.
MedLine Citation:
PMID:  1612085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythropoietic adaptations involving the oxygen dissociation curve (ODC) and erythropoietin production have been implicated in the etiology of reduced blood haemoglobin concentrations in sportspersons (known as sports anaemia). A significant increase in the half-saturation pressure indicating a right-shift in the ODC was measured in 34 male [25.8-27.4 mmHg (3.44-3.65 kPa)] and 16 female (25.8-27.7 mmHg (3.44-3.69 kPa)] trained distance runners (P less than 0.01 for both genders) after completing a standard 42-km marathon. Erythrocyte 2,3-diphosphoglycerate concentrations measured concurrently were unaltered by exercise, although consistently higher in the female compared to the male athletes (P less than 0.05). The serum erythropoietin (EPO) concentrations of 15 male triathletes (26.3 U.ml-1) were significantly lower than those of 45 male distance runners (31.6 U.ml-1; P less than 0.05). However, the mean serum EPO concentrations of male and female athletes engaged in a variety of sports were not different from those of sedentary control subjects of both sexes (26.5-35.3 U.ml-1). Furthermore, the serum EPO concentrations were unaltered after prolonged strenuous exercise in 20 male marathon runners. These data suggest that the haematological status of these endurance athletes is in fact normal and that the observed shift in the ODC, while providing a physiological advantage during exercise, has no measurable effect on the erythropoietic drive.
Authors:
L M Weight; D Alexander; T Elliot; P Jacobs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  64     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1992  
Date Detail:
Created Date:  1992-07-24     Completed Date:  1992-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  444-8     Citation Subset:  IM    
Affiliation:
University of Cape Town Leukaemia Centre, South Africa.
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MeSH Terms
Descriptor/Qualifier:
2,3-Diphosphoglycerate
Adaptation, Physiological*
Adult
Anemia / blood,  etiology
Diphosphoglyceric Acids / blood
Erythropoiesis / physiology*
Erythropoietin / blood
Female
Hemoglobins / metabolism
Humans
Male
Oxygen / blood
Physical Education and Training
Physical Endurance / physiology*
Chemical
Reg. No./Substance:
0/Diphosphoglyceric Acids; 0/Hemoglobins; 11096-26-7/Erythropoietin; 138-81-8/2,3-Diphosphoglycerate; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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