Document Detail


Erythropoietic activities in acute leukemia and in malignant lymphoma with or without bone marrow involvement.
MedLine Citation:
PMID:  14584754     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythropoietic activities and immature reticulocyte production were investigated in a total of 157 patients (81 men, 76 women, median age = 42 yr, range = 23 to 65 yr) with acute lymphoid leukemia (ALL, n = 31), acute myeloid leukemia (AML, n = 39), or non-Hodgkin's lymphoma (NHL, n = 87), based on assays of the hemogram, red cell indices, reticulocyte subpopulations, and intramedullary erythroid precursors. There were no significant differences in red blood cell (RBC) counts, blood hemoglobin levels, or erythroid precursors between ALL and AML patients. Reticulocytes in AML patients averaged 1.7 +/- 0.8%, which was higher than in patients with ALL (0.8 +/- 0.3%, p <0.01); the proportion of high-fluorescence reticulocytes (HFR) averaged 4-fold higher in AML versus ALL (p <0.01) and the reticulocyte maturity index (RMI) was higher in AML (20.8 +/- 8.3%) versus ALL (12.4 +/- 6.5%, p <0.01). The RMI was higher in NHL patients with bone marrow (BM) involvement (15.6 +/- 9.4%), compared to those without BM involvement (4.3 +/- 2.1%, p <0.01). The proportion of HFR averaged 11-fold higher in NHL with BM involvement versus NHL without BM involvement. In summary, erythropoietic activity is significantly more active in patients with AML compared to ALL and in patients with NHL with BM involvement, compared to NHL without BM involvement.
Authors:
Jong Weon Choi; Soo Hwan Pai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  33     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-30     Completed Date:  2004-05-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  407-10     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine, College of Medicine, Inha University, Inchon, South Korea. jwchoi@inha.ac.kr
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Marrow / pathology*
Cell Division
Erythropoiesis*
Female
Humans
Leukemia, Myeloid, Acute / blood*
Lymphoma, Non-Hodgkin / blood*,  pathology*
Male
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood*
Reticulocytes / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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