| Erythropoiesis-stimulating agents. | |
| | |
MedLine Citation:
|
PMID: 21052950 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Erythropoiesis is the process whereby erythroid progenitor cells differentiate and divide, resulting in increased numbers of red blood cells (RBCs). RBCs contain hemoglobin, the main oxygen carrying component in blood. The large number of RBCs found in blood is required to support the prodigious consumption of oxygen by tissues as they undergo oxygen-dependent processes. Erythropoietin is a hormone that when it binds and activates Epo receptors resident on the surface of cells results in stimulation of erythropoiesis. Successful cloning of the EPO gene allowed for the first time production of recombinant human erythropoietin and other erythropoiesis stimulating agents (ESAs), which are used to treat anemia in patients. In this chapter, the control of Epo levels and erythropoiesis, the various forms of ESAs used commercially, and their physical and biological properties are discussed. |
| | |
Authors:
|
Steve Elliott |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cancer treatment and research Volume: 157 ISSN: 0927-3042 ISO Abbreviation: Cancer Treat. Res. Publication Date: 2011 |
Date Detail:
|
Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8008541 Medline TA: Cancer Treat Res Country: United States |
Other Details:
|
Languages: eng Pagination: 55-74 Citation Subset: IM |
Affiliation:
|
Department of Hematology, Amgen, Inc., Thousand Oaks, CA 91320, USA. selliott@amgen.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Granulocyte colony-stimulating factors.
Next Document: Thrombopoietin factors.