Document Detail


Erythropoiesis in infants of diabetic mothers.
MedLine Citation:
PMID:  3945525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal polycythemia is a well-established perinatal complication in infants of diabetic mothers (IDM). To investigate the regulation of erythropoiesis in these infants, we measured cord blood erythropoietin (EP) levels by a sensitive radioimmune assay and examined the growth of erythroid progenitor colonies in a series of IDM and control infants. Fifteen of 18 diabetic mothers were managed on a protocol emphasizing careful glycemic control throughout pregnancy; 10 had glycosolated hemoglobin values within the normal, nondiabetic range during the third trimester. Cord blood EP was elevated in one of 18 IDM and in two of 13 controls (p = NS). In IDM, cord blood EP values were higher in infants delivered following maternal labor and were inversely correlated with umbilical artery pH (r = -0.72; p = 0.006). Growth of burst forming units-erythroid was similar in IDM and controls in the presence of 0.1 to 2.0 U of exogenous EP per ml of methylcellulose medium. Individual infants tended to respond consistently over the entire range of EP doses tested. The number of burst forming units-erythroid observed did not correlate with cord blood EP, birth weight, or neonatal hematocrits. We conclude that: umbilical cord blood EP levels are generally normal in IDM delivered by mothers in whom good glycemic control is maintained throughout gestation, cord blood EP values are strongly influenced by perinatal events, and the response of erythroid progenitors to EP is intrinsically normal in IDM. These data suggest that polycythemia is an adaptive response in IDM and is not associated with a primary abnormality in erythropoiesis.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
K Shannon; J C Davis; J L Kitzmiller; S A Fulcher; H M Koenig
Related Documents :
22385055 - New pharmacological approaches in infants with hypoxic-ischemic encephalopathy.
18951215 - Prenatal buprenorphine exposure: effects on biochemical markers of hypoxia and early ne...
15292345 - Cord plasma adiponectin: a 20-fold rise between 24 weeks gestation and term.
7720255 - Los angeles county-university of southern california medical center clinical pathology ...
25213275 - The otolaryngologist's role in newborn hearing screening and early intervention.
25108865 - Detection of cronobacter species in powdered infant formula by probe-magnetic separatio...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  20     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-03-18     Completed Date:  1986-03-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Glucose / metabolism
Cells, Cultured
Diabetes Mellitus, Type 1 / physiopathology
Erythropoiesis* / drug effects
Erythropoietin / blood*
Female
Fetal Blood / analysis*
Hematocrit
Humans
Infant, Newborn*
Polycythemia / prevention & control
Pregnancy
Pregnancy in Diabetics / physiopathology*,  therapy
Radioimmunoassay
Stem Cells / physiology
Chemical
Reg. No./Substance:
0/Blood Glucose; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute polycythemia increases the disappearance rate of clottable fibrinogen in the newborn dog.
Next Document:  Drinking patterns and social consequences: a study of middle-class adolescents in two private pediat...