Document Detail


Erythrophagocytosis in de novo-philadelphia-positive acute leukemia of ambiguous lineage.
MedLine Citation:
PMID:  16923527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythrophagocytosis by neoplastic cells in acute leukemia has been most frequently associated with FAB M4 and M5 subtypes, with the t(8;16) and with C-MOZ rearrangements, however it is exceptional in acute lymphoblastic leukemia and has not been previously reported in Philadelphia-positive (Ph+) acute leukemia. We herein present a case of Ph+ acute leukemia of ambiguous lineage in which erythrophagocytosis is an outstanding feature. The implications between the different postulated leukemogenic pathways and the hypothesized mechanism of erythrophagocytosis are concisely reviewed and discussed.
Authors:
Francisco J Ortuño; Cristina Castilla; Maria J Moreno; Maria del Mar Osma; Marcos Gonzalez; Vicente Vicente
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Haematologica     Volume:  91     ISSN:  1592-8721     ISO Abbreviation:  Haematologica     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-22     Completed Date:  2006-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  ECR43     Citation Subset:  IM    
Affiliation:
Hematology and Clinical Oncology Department, Morales Meseguer University Hospital, Murcia, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Erythrocytes / pathology*
Humans
Leukemia / genetics,  pathology*
Male
Phagocytosis / physiology
Philadelphia Chromosome*

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