Document Detail


Erythrophagocytosis of desialylated red blood cells is responsible for anaemia during T. vivax infection.
MedLine Citation:
PMID:  23421946     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Trypanosomal infection-induced anaemia is a devastating scourge for cattle in widespread regions. Although T. vivax is considered as one of the most important parasites regarding economic impact in Africa and South America, very few in-depth studies have been conducted due to the difficulty of manipulating this parasite. Several hypotheses were proposed to explain trypanosome induced-anaemia but mechanisms have not yet been elucidated. Here, we characterized a multigenic family of trans-sialidases in T. vivax, some of which are released into the host serum during infection. These enzymes are able to trigger erythrophagocytosis by desialylating the major surface erythrocytes sialoglycoproteins, the glycophorins. Using an ex vivo assay to quantify erythrophagocytosis throughout infection, we showed that erythrocyte desialylation alone results in significant levels of anaemia during the acute phase of the disease. Characterization of virulence factors such as the trans-sialidases is vital to develop a control strategy against the disease or parasite.
Authors:
Fabien Guegan; Nicolas Plazolles; Théo Baltz; Virginie Coustou
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-20
Journal Detail:
Title:  Cellular microbiology     Volume:  -     ISSN:  1462-5822     ISO Abbreviation:  Cell. Microbiol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883691     Medline TA:  Cell Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Blackwell Publishing Ltd.
Affiliation:
Univ. de Bordeaux, Microbiologie fondamentale et Pathogénicité, UMR 5234, F-33000, Bordeaux, France; CNRS, Microbiologie fondamentale et Pathogénicité, UMR 5234, F-33000, Bordeaux, France.
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