Document Detail

Erythromycin versus tetracycline for treatment of Mediterranean spotted fever.
MedLine Citation:
PMID:  3535687     Owner:  NLM     Status:  MEDLINE    
Eighty one children aged between 1 and 13 years participated in a randomised comparative trial of tetracycline hydrochloride and erythromycin stearate for treatment of Mediterranean spotted fever. Both therapeutic regimens proved effective, but in patients treated with tetracycline both clinical symptoms and fever disappeared significantly more quickly. Likewise, when those patients who began treatment within the first 72 hours of illness are considered the febrile period had a significantly shorter duration in the group treated with tetracycline. One patient was switched to tetracycline because there was no improvement of clinical manifestations, with persistence of fever, myalgias, and prostration, after receiving eight days of treatment with erythromycin. These results suggest that tetracyclines are superior to erythromycin in the treatment of Mediterranean spotted fever.
T Muñoz-Espin; P López-Parés; E Espejo-Arenas; B Font-Creus; I Martinez-Vila; J Travería-Casanova; F Segura-Porta; F Bella-Cueto
Related Documents :
22291767 - Redo surgery risk in patients with cardiac prosthetic valve dysfunction.
22676547 - Short-term neurodevelopmental outcomes in neonates with congenital heart disease: the e...
25143637 - High sensitive c-reactive protein-effective tool in determining postoperative recovery ...
3501857 - Treatment of acute exacerbations of chronic bronchitis with ciprofloxacin.
24145687 - The effect of steroids on the incidence of gastrointestinal hemorrhage after spinal cor...
16226517 - Risk of sudden visual loss following filtration surgery in end-stage glaucoma.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  61     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-12-18     Completed Date:  1986-12-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1027-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Boutonneuse Fever / drug therapy*
Child, Preschool
Clinical Trials as Topic
Erythromycin / analogs & derivatives*,  therapeutic use
Random Allocation
Tetracycline / therapeutic use*
Time Factors
Reg. No./Substance:
114-07-8/Erythromycin; 60-54-8/Tetracycline; 643-22-1/erythromycin stearate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Slow release theophylline in preschool asthmatics.
Next Document:  Fetal lymphangiectasia--another cause for a positive amniotic fluid acetylcholinesterase test.