| Erythromycin therapy for otitis media with effusion in sinobronchial syndrome. | |
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MedLine Citation:
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PMID: 8499096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic sinusitis is frequently associated with chronic lower respiratory tract diseases, and the association is referred to as sinobronchial syndrome (SBS). This study was carried out to determine the incidence of otitis media with effusion in the patients with sinobronchial syndrome and to investigate the efficacy of low-dose and long-term erythromycin therapy for otitis media with effusion associated with sinobronchial syndrome. We have found a high incidence of otitis media with effusion in patients with sinobronchial syndrome, the morbidity rate being 54% in 50 cases studied. This ear disease seems to be the major cause of hearing disturbance in patients with sinobronchial syndrome. Sixteen patients with both sinobronchial syndrome and otitis media with effusion were given low-dose and long-term erythromycin therapy (erythromycin base, 600 mg/d for more than 4 months); of these, 13 became effusion-free and most subjects showed improvement in the symptoms of sinobronchial syndrome. The erythromycin therapy thus seems to be exceedingly effective for the treatment of sinobronchial syndrome and associated otitis media with effusion. |
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Authors:
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Y Iino; K Sugita; M Toriyama; K Kudo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of otolaryngology--head & neck surgery Volume: 119 ISSN: 0886-4470 ISO Abbreviation: Arch. Otolaryngol. Head Neck Surg. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-06-30 Completed Date: 1993-06-30 Revised Date: 2006-03-28 |
Medline Journal Info:
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Nlm Unique ID: 8603209 Medline TA: Arch Otolaryngol Head Neck Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 648-51 Citation Subset: AIM; IM |
Affiliation:
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Department of Otolaryngology, National Medical Center, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adolescent Adult Aged Aged, 80 and over Asthma / drug therapy* Bronchiectasis / drug therapy* Bronchiolitis / drug therapy* Bronchitis / drug therapy* Chronic Disease Drug Evaluation Erythromycin / administration & dosage* Female Humans Male Middle Aged Otitis Media with Effusion / drug therapy* Sinusitis / drug therapy* Syndrome Time Factors |
| Chemical | |
Reg. No./Substance:
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114-07-8/Erythromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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