Document Detail

Erythromycin therapy in preterm premature rupture of the membranes: a prospective, randomized trial of 220 patients.
MedLine Citation:
PMID:  1550145     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The use of prophylactic antibiotics in the management of preterm premature rupture of the membranes has not been adequately studied. The purpose of this study was to evaluate the efficacy of oral erythromycin therapy in the prolongation of latency and reduction of infectious morbidity after preterm premature rupture of membranes. STUDY DESIGN: In this randomized, prospective, double-blind, placebo-controlled study, 220 women at 20 to 35 weeks' gestation were evaluated. Subjects received oral erythromycin 333 mg (n = 106) or indistinguishable placebo (n = 114) every 8 hours from randomization to delivery. RESULTS: Prolongation of latency was identified with erythromycin therapy (p = 0.02), particularly for those destined to have chorioamnionitis (p = 0.003) and those with oligohydramnios (p = 0.01). No decrease in the incidence of maternal or neonatal infectious morbidity was seen. CONCLUSIONS: Oral erythromycin delays, but does not prevent, the onset of clinical infection when administered to women with preterm premature rupture of membranes. This regimen does not decrease neonatal morbidity and mortality.
B M Mercer; M L Moretti; R R Prevost; B M Sibai
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  166     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-20     Completed Date:  1992-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  794-802     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103.
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MeSH Terms
Delivery, Obstetric
Double-Blind Method
Erythromycin / therapeutic use*
Fetal Membranes, Premature Rupture / drug therapy*
Infection Control / methods
Pregnancy Outcome
Prospective Studies
Time Factors
Vaginal Smears
Reg. No./Substance:

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