| Erythromycin therapy in preterm premature rupture of the membranes: a prospective, randomized trial of 220 patients. | |
| | |
MedLine Citation:
|
PMID: 1550145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: The use of prophylactic antibiotics in the management of preterm premature rupture of the membranes has not been adequately studied. The purpose of this study was to evaluate the efficacy of oral erythromycin therapy in the prolongation of latency and reduction of infectious morbidity after preterm premature rupture of membranes. STUDY DESIGN: In this randomized, prospective, double-blind, placebo-controlled study, 220 women at 20 to 35 weeks' gestation were evaluated. Subjects received oral erythromycin 333 mg (n = 106) or indistinguishable placebo (n = 114) every 8 hours from randomization to delivery. RESULTS: Prolongation of latency was identified with erythromycin therapy (p = 0.02), particularly for those destined to have chorioamnionitis (p = 0.003) and those with oligohydramnios (p = 0.01). No decrease in the incidence of maternal or neonatal infectious morbidity was seen. CONCLUSIONS: Oral erythromycin delays, but does not prevent, the onset of clinical infection when administered to women with preterm premature rupture of membranes. This regimen does not decrease neonatal morbidity and mortality. |
| | |
Authors:
|
B M Mercer; M L Moretti; R R Prevost; B M Sibai |
Related Documents
:
|
21701205 - Growth factors, stem cells and bronchopulmonary dysplasia. 11167205 - Ethical implications of aggressive obstetric management at less than 28 weeks of gestat... 20732945 - Neonatal outcomes of extremely preterm infants from the nichd neonatal research network. 16929415 - Adverse maternal and neonatal outcome of prolonged course of magnesium sulfate tocolysis. 12070435 - Symptomatic annular pancreas in newborns. 16503785 - Survivorship and mortality implications of developmental 670-nm phototherapy: dioxin co... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 166 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1992 Mar |
Date Detail:
|
Created Date: 1992-04-20 Completed Date: 1992-04-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 794-802 Citation Subset: AIM; IM |
Affiliation:
|
Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Delivery, Obstetric Double-Blind Method Erythromycin / therapeutic use* Female Fetal Membranes, Premature Rupture / drug therapy* Humans Infection Control / methods Pregnancy Pregnancy Outcome Prospective Studies Time Factors Vaginal Smears |
| Chemical | |
Reg. No./Substance:
|
114-07-8/Erythromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Early menopause in long-term survivors of cancer during adolescence.
Next Document: Efficacy of the fetal-pelvic index in nulliparous women at high risk for fetal-pelvic disproportion.