Document Detail

Erythromycin increases gastric antral motility in human premature infants.
MedLine Citation:
PMID:  8373908     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine if erythromycin (EM), which is a potent motilin agonist, alters gastrointestinal motility in premature infants. Six infants who were born after 23-30 weeks gestation and weighed 825-1,408 g at birth were studied when 6-31 days old. Intraluminal pressure changes within the gastric antrum and proximal duodenum were recorded. We infused EM 0.75 mg/kg intravenously for 15 min and we compared gastric and duodenal contractions for 30 min between before and after the initiation of EM infusion. In these preterm infants the migrating complex was not present, and was not induced by EM. However, in all 6 infants EM increased nonpropagating antral clusters of contractions (p < 0.05). The antral motility index increased 4-fold (p < 0.05). We concluded that human premature infants have functioning motilin receptors.
T Tomomasa; M Miyazaki; T Koizumi; T Kuroume
Related Documents :
12598378 - Hib vaccination in infants born prematurely.
18843588 - Periventricular leukomalacia in premature infants in mainland china.
15580358 - Haemophilia a in two premature infants.
7204558 - Fat digestion in the newborn. characterization of lipase in gastric aspirates of premat...
17685328 - Survival of enterobacter sakazakii in powdered infant formula as affected by compositio...
16702278 - Pre-conception energy balance and secondary sex ratio--partial support for the trivers-...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  63     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1993  
Date Detail:
Created Date:  1993-10-21     Completed Date:  1993-10-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  349-52     Citation Subset:  IM    
Department of Pediatrics, Gunma University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Duodenum / drug effects,  physiology
Erythromycin / administration & dosage,  pharmacology*
Gastrointestinal Motility / drug effects*
Infant, Newborn
Infant, Premature*
Infusions, Intravenous
Pyloric Antrum / drug effects,  physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Analysis of risk factors influencing imminent distress in growth-retarded fetuses undergoing oxygen ...
Next Document:  Effects of hyperbaric oxygen on rat embryos.