| Erythromycin increases gastric antral motility in human premature infants. | |
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MedLine Citation:
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PMID: 8373908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine if erythromycin (EM), which is a potent motilin agonist, alters gastrointestinal motility in premature infants. Six infants who were born after 23-30 weeks gestation and weighed 825-1,408 g at birth were studied when 6-31 days old. Intraluminal pressure changes within the gastric antrum and proximal duodenum were recorded. We infused EM 0.75 mg/kg intravenously for 15 min and we compared gastric and duodenal contractions for 30 min between before and after the initiation of EM infusion. In these preterm infants the migrating complex was not present, and was not induced by EM. However, in all 6 infants EM increased nonpropagating antral clusters of contractions (p < 0.05). The antral motility index increased 4-fold (p < 0.05). We concluded that human premature infants have functioning motilin receptors. |
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Authors:
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T Tomomasa; M Miyazaki; T Koizumi; T Kuroume |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biology of the neonate Volume: 63 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1993 |
Date Detail:
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Created Date: 1993-10-21 Completed Date: 1993-10-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 349-52 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Gunma University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Duodenum
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drug effects,
physiology Erythromycin / administration & dosage, pharmacology* Gastrointestinal Motility / drug effects* Humans Infant, Newborn Infant, Premature* Infusions, Intravenous Pyloric Antrum / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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114-07-8/Erythromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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