Document Detail


Erythromycin increases gastric antral motility in human premature infants.
MedLine Citation:
PMID:  8373908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to determine if erythromycin (EM), which is a potent motilin agonist, alters gastrointestinal motility in premature infants. Six infants who were born after 23-30 weeks gestation and weighed 825-1,408 g at birth were studied when 6-31 days old. Intraluminal pressure changes within the gastric antrum and proximal duodenum were recorded. We infused EM 0.75 mg/kg intravenously for 15 min and we compared gastric and duodenal contractions for 30 min between before and after the initiation of EM infusion. In these preterm infants the migrating complex was not present, and was not induced by EM. However, in all 6 infants EM increased nonpropagating antral clusters of contractions (p < 0.05). The antral motility index increased 4-fold (p < 0.05). We concluded that human premature infants have functioning motilin receptors.
Authors:
T Tomomasa; M Miyazaki; T Koizumi; T Kuroume
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  63     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1993  
Date Detail:
Created Date:  1993-10-21     Completed Date:  1993-10-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  349-52     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Gunma University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Duodenum / drug effects,  physiology
Erythromycin / administration & dosage,  pharmacology*
Gastrointestinal Motility / drug effects*
Humans
Infant, Newborn
Infant, Premature*
Infusions, Intravenous
Pyloric Antrum / drug effects,  physiology*
Chemical
Reg. No./Substance:
114-07-8/Erythromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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