Document Detail

Erythromycin and feeding intolerance in premature infants: a randomized trial.
MedLine Citation:
PMID:  17036029     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the effectiveness of low-dose oral erythromycin to treat feeding intolerance in preterm infants. DESIGN: This study was a prospective, double-blind, randomized, placebo-controlled trial on 60 premature infants suffering from feeding intolerance. Thirty infants were given oral erythromycin 1 mg/kg every 8 h and 30 infants were given placebo (normal saline). Randomization was stratified on enrollment according to gestational age whether >32 weeks or <or=32 weeks. The primary end point was the length of time taken to establish full enteral feeding since enrollment. Potential adverse effects associated with erythromycin were also monitored. Groups of each corresponding stratum were compared using two-tail t-test and Mann-Whitney for continuous variables, and chi (2) and Fisher's exact for categorical variables. RESULTS: For infants with gestational age >32 weeks, the erythromycin group achieved full enteral feeding earlier than placebo group (10.5+/-4.1 vs 16.3+/-5.7 days, respectively; P=0.01) had fewer episodes of gastric residuals (P<0.05) and shorter duration of parenteral nutrition (PN) (P<0.05). On the other hand, in infants with gestational age <or=32 weeks, there were no significant differences between erythromycin and placebo groups regarding any of these variables. CONCLUSION: Low-dose enteral erythromycin is associated with better tolerance of feeding and shorter duration of PN in infants >32 weeks gestation. A similar effect on younger preterm infants was not demonstrable.
H Aly; H Abdel-Hady; M Khashaba; N El-Badry
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-10-12
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  27     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-20     Completed Date:  2007-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Department of Neonatology, The George Washington University Hospital, Washington, DC 20037, USA.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Double-Blind Method
Enteral Nutrition*
Erythromycin / therapeutic use*
Gastrointestinal Agents / therapeutic use*
Gastrointestinal Motility / drug effects*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gastrointestinal Agents; 114-07-8/Erythromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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