Document Detail

Erythromycin enhances oesophageal motility in patients with gastro-oesophageal reflux.
MedLine Citation:
PMID:  11413601     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intravenous (i.v.) erythromycin enhances gastric emptying and oesophageal motility in both healthy and disease situations, acting either as a motilin or acetylcholine agonist. The purpose of the present paper was to investigate any possible effect of i.v. erythromycin on oesophageal motility in patients with gastro-oesophageal reflux (GOR). METHODS: In 15 patients with GOR (proven on 24-h ambulatory oesophageal pH measurement), standard oesophageal manometry was performed after i.v. injection of placebo and 200 mg erythromycin, in a random blind fashion. RESULTS: Erythromycin significantly increased lower oesophageal sphincter (LOS) pressure from 17 +/- 5 to 41 +/- 10 mmHg (P < 0.001), without affecting the postdeglutition relaxation of LOS. Erythromycin also increased the amplitude (from 79 +/- 34 to 97 +/- 40 mmHg; P < 0.001), duration (from 3.4 +/- 0.6 to 3.8 +/- 0.6 s; P = 0.005), velocity (from 3.1 +/- 0.8 to 3.5 +/- 1.15 cm/s; P = 0.0047) and strength (from 149 +/- 84 to 201 +/- 103 mmHg.s; P < 0.001) of peristalsis at 5 cm proximal to the LOS. Similarly, the drug increased the amplitude of peristalsis at 10 and 15 cm proximal to the LOS (from 70 +/- 39 to 77.4 +/- 37 mmHg; P = 0.049 and from 36 +/- 20 to 49 +/- 36 mmHg; P = 0.004, respectively) and the duration of peristalsis at the same levels (from 3.1 +/- 0.6 to 3.3 +/- 0.5 s; P = 0.011, and from 2.7 +/- 0.6 to 3 +/- 0.5 s; P = 0.003, respectively). CONCLUSION: Intravenously administered erythromycin improves impaired oesophageal motility in patients with GOR. This observation might be of clinical use.
E Chrysos; G Tzovaras; E Epanomeritakis; J Tsiaoussis; N Vrachasotakis; J S Vassilakis; E Xynos
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  ANZ journal of surgery     Volume:  71     ISSN:  1445-1433     ISO Abbreviation:  ANZ J Surg     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-06-20     Completed Date:  2001-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101086634     Medline TA:  ANZ J Surg     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  98-102     Citation Subset:  IM    
Department of General Surgery, University Hospital of Heraklion, Heraklion, Crete GR-711 10, Greece.
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MeSH Terms
Double-Blind Method
Erythromycin / administration & dosage*,  adverse effects
Esophageal Motility Disorders / drug therapy*
Esophagogastric Junction / drug effects
Gastric Acidity Determination
Gastric Emptying / drug effects*
Gastroesophageal Reflux / drug therapy*
Injections, Intravenous
Middle Aged
Monitoring, Ambulatory
Reg. No./Substance:

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