Document Detail


Erythroid abnormalities in rheumatoid arthritis: the role of erythropoietin.
MedLine Citation:
PMID:  1491387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythroid alterations were studied in 136 patients with rheumatoid arthritis (RA). Anemia was present in 75 cases. A definite diagnosis was determined in 65. The most frequent anemia was that of chronic disease (ACD) (43 cases); 14 patients with ACD presented with moderate to severe anemia. Prevalence of deficiencies were also high (15 cases had iron deficiency anemia, IDA). Serum erythropoietin levels were different in patients with RA compared with a healthy control group (p < 0.00001). Serum erythropoietin was increased in ACD (49 +/- 28.8 U/l) with respect to both RA (38.6 +/- 12.7 U/l, p = 0.0036) and controls (18.2 +/- 7.6 U/l, p < 0.00001). Although hemoglobin (Hb) was similar in ACD and IDA, serum erythropoietin in ACD was lower than in IDA (p = 0.01). There was a negative relationship between Hb and serum erythropoietin in ACD (r = -0.42, p = 0.005). In conclusion, almost 50% of patients with RA have anemia and ACD is the most frequent. As serum erythropoietin in ACD is blunted, patients with moderate to severe ACD are possible candidates for erythropoietin treatment.
Authors:
A F Remacha; A Rodríguez-de la Serna; F García-Dié; C Geli; C Díaz; E Gimferrer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  19     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-03-04     Completed Date:  1993-03-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1687-91     Citation Subset:  IM    
Affiliation:
Hematology Department, Sant Pau Hospital, Autonomous University of Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anemia / blood,  complications*,  epidemiology
Arthritis, Rheumatoid / blood,  complications*,  physiopathology
Chronic Disease
Erythropoietin / blood,  physiology*
Female
Folic Acid Deficiency / blood,  complications,  epidemiology
Humans
Male
Middle Aged
Prevalence
Prospective Studies
Vitamin B 12 Deficiency / blood,  complications,  epidemiology
Chemical
Reg. No./Substance:
11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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