| Erythrogenic toxin-induced arteritis in a rabbit ear model. Comparison with Arthus reaction angiitis. | |
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MedLine Citation:
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PMID: 9331774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have developed a local type experimental model of angiitisin rabbits. Repeated intracutaneous injections of erythrogenic toxins types A and C (ETA, ETC) along the intermediate auricular artery of the rabbit ear produced subacute type arteritis, characteristic of lymphocyticinfiltration, simulating Kawasaki disease angiitis. Staphylococcal enterotoxin B (SEB) and toxic shock syndrome toxin 1 (TSST) also induced similar lesions, indicating superantigens as inflammogens in vivo. Conversely, the Arthus reaction included acute type angiitis when tested similarly in rabbits immunized to human serum albumin. The ear artery was infiltrated by heterophil leukocytes, often together with venules and capillaries affected, resembling periarteritis nodosa and leukoclastic vasculitis in human disease. |
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Authors:
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Y Abe; S Nakano; K Aita; M Sagishima |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 418 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-12-09 Completed Date: 1997-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 805-7 Citation Subset: IM |
Affiliation:
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Department of Pathology, School of Medicine, Teikyo University, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteritis / etiology*, pathology Arthus Reaction / etiology*, pathology Bacterial Proteins* Disease Models, Animal Ear / blood supply Exotoxins / toxicity* Humans Lymphocytes / pathology Membrane Proteins* Rabbits Superantigens / toxicity Vasculitis / etiology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Exotoxins; 0/Membrane Proteins; 0/SpeA protein, Streptococcus pyogenes; 0/Superantigens; 0/erythrogenic toxin |
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