Document Detail

Erythrodermic CTCL: updated clues to diagnosis and treatment.
MedLine Citation:
PMID:  23149699     Owner:  NLM     Status:  Publisher    
Erythroderma is a rare but severe cutaneous condition characterized from a clinical point of view by a complete involvement (as per definition more than 80% body surface) of the skin surface. Pre-existing dermatoses account for about 70% of erythroderma cases, drug reactions are responsible for erythroderma in about 20%, whilst primary cutaneous T-cell lymphoma (CTCL) constitute less than 10% of and are represented by erythrodermic mycosis fungoides and Sézary syndrome. The challenge in these patients is represented by the identification of the etiological agents or conditions, which is clearly of overwhelming relevance in the clinical management and treatment strategies. In recent years, the development of multiparameter flow-cytometry, which allows to identify specific antigens expressed or not expressed on the surface of atypical lymphoid T-cells, and T-cell molecular biology techniques, which are aimed to identify the presence of a clonal T-cell population in the skin and blood on the basis of the finding of rearrangement of the T-cell receptor, have represented relevant useful tool in the differential diagnosis between benign and lymphomatous erythroderma. Moreover, a better understanding of the immunological and molecular pathways in CTCL disease evolution provided the identification of specific therapeutical targets, as well as the constant improvement in the laboratory techniques lead to the development of new and promising agents in CTCL.
M G Bernengo; P Quaglino
Related Documents :
24582309 - Mastocytosis associated with a rare germline kit k509i mutation displays a well-differe...
25060689 - Leptin modulates autophagy in human cd4(+)cd25(-) conventional t cells.
9062799 - Cell-, tissue-, and position-specific monoclonal antibodies against the planarian duges...
24010859 - Fcer2 (cd23) asthma-related snp yields increased ige binding and egr-1 expression in hu...
24405639 - Hypermethylation of the alternative awt1 promoter in hematological malignancies is a hi...
25003789 - Notch intracellular domain deficient in nuclear localization activity retains the abili...
22359119 - Characterization and applications of lymphocytic clonal growth factor in human plasma.
15906379 - Neurod1 in the endocrine pancreas: localization and dual function as an activator and r...
10962809 - Interleukin 2 induction of proliferation in resting t lymphocytes requires contact with...
Publication Detail:
Journal Detail:
Title:  Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia     Volume:  147     ISSN:  0392-0488     ISO Abbreviation:  G Ital Dermatol Venereol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102852     Medline TA:  G Ital Dermatol Venereol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  533-544     Citation Subset:  -    
Dermatologic Clinic, Department of Medical Sciences University of Turin, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mycosis fungoides: disease evolution of the "lion queen" revisited.
Next Document:  CD30+ lymphoproliferative disorders of the skin: still an open question.