Document Detail

Erythrodermia induced by omeprazole.
MedLine Citation:
PMID:  11380068     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a case of erythrodermia that appears to be related to the intake of omeprazole (OMP) for treatment of gastroesophageal reflux disease. CASE SUMMARY: We describe a case of erythrodermia associated with OMP therapy in a 58-year-old white woman with no predisposing factors. In 1995, at the Rheumatology Outpatients' Clinic, she was diagnosed as having scleroderma (CREST subgroup) and Sjögren's syndrome associated with corticoid osteoporosis and multiple crushed vertebrae, Raynaud's disease and joint pain. In March 1998, treatment with OMP 20 mg/d p.o. was started for treatment of gastroesophageal reflux disease. She came to our hospital emergency room in October 1999 because of a severe cutaneous reaction and poor general health. The dermatology service diagnosed the erythrodermia as a skin reaction to medication. We suspected that the causative agent was OMP. Examination of a skin biopsy specimen demonstrated that it was compatible with a toxicodermic reaction to medication. Administration of OMP was suspended and the skin lesions and the patient's general state of health improved. She was discharged without symptoms. CONCLUSIONS: Our case reports, and others from the literature, suggest the importance of recognizing of the possibility of cutaneous adverse drug reactions even with medications, such as OMP, which has a good safety profile. Caution is recommended with the use of OMP, especially in elderly patients, in patients with renal insufficiency or decompensating liver disease and in patients who receive drugs that affect OMP metabolism.
J Borrás-Blasco; A Navarro-Ruiz; F Navarro-Blasco; J Tovar-Beltran; M González-Delgado
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  International journal of clinical pharmacology and therapeutics     Volume:  39     ISSN:  0946-1965     ISO Abbreviation:  Int J Clin Pharmacol Ther     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-29     Completed Date:  2001-10-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9423309     Medline TA:  Int J Clin Pharmacol Ther     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  219-23     Citation Subset:  IM    
Pharmacy Service, Hospital General Universitario de Elche, Spain.
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MeSH Terms
Anti-Ulcer Agents / adverse effects*
Dermatitis, Exfoliative / chemically induced*,  pathology
Middle Aged
Omeprazole / adverse effects*
Reg. No./Substance:
0/Anti-Ulcer Agents; 73590-58-6/Omeprazole

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