Document Detail

Erythrocyte volume distribution analysis and hematologic changes in two horses with immune-mediated hemolytic anemia.
MedLine Citation:
PMID:  6623846     Owner:  NLM     Status:  MEDLINE    
Immune-mediated hemolytic anemia was diagnosed in two horses on the basis of regenerative anemia, increased erythrocyte fragility in hypotonic saline, autoagglutination, and a positive direct antiglobulin (Coomb's) test. During steroid therapy partial resolution of the anemia was indicated by rising packed cell volume, macrocytosis, and bone marrow erythroid hyperplasia. Using erythrocyte volume distribution histograms (erythrograms), the regenerative response was characterized by analysis of macrocytic and normocytic erythrocyte subpopulations. In both horses, a gradual net increase of about 2 X 10(6) macrocytes/microliter occurred over a four- to five-week period. Over the same interval there was a gradual decrease in the number of normocytes. We suggest that the macrocytes remained large through this period rather than contributing to normocyte population growth. Erythrograms may provide an additional means of evaluating erythrocyte regeneration in horses.
G Weiser; C Kohn; A Vachon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  20     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  424-33     Citation Subset:  IM    
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MeSH Terms
Anemia, Hemolytic, Autoimmune / diagnosis,  veterinary*
Bone Marrow Examination / veterinary
Dog Diseases / diagnosis
Erythrocyte Count / veterinary
Erythrocyte Indices / veterinary
Hematocrit / veterinary
Horse Diseases / diagnosis*
Osmotic Fragility

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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