Document Detail


Erythrocyte stearidonic acid and other n-3 fatty acids and CHD in the Physicians' Health Study.
MedLine Citation:
PMID:  23098619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intake of marine-based n-3 fatty acids (EPA, docosapentaenoic acid and DHA) is recommended to prevent CHD. Stearidonic acid (SDA), a plant-based n-3 fatty acid, is a precursor of EPA and may be more readily converted to EPA than a-linolenic acid (ALA). While transgenic soyabeans might supply SDA at low cost, it is unclear whether SDA is associated with CHD risk. Furthermore, associations of other n-3 fatty acids with CHD risk remain inconsistent. The present ancillary study examined the association of erythrocyte SDA as well as other n-3 fatty acids with the risk of CHD. In a prospective nested case-control study of the Physicians' Health Study, we randomly selected 1000 pairs of incident CHD with matching controls. Erythrocyte fatty acids were measured using GC. We used conditional logistic regression to estimate relative risks. Mean age was 68·7 (SD 8·7) years. In a multivariable model controlling for matching factors and established CHD risk factors, OR for CHD for each standard deviation increase of log-SDA was 1·03 (95% CI 0·90, 1·18). Corresponding values for log-ALA and log-marine n-3 fatty acids were 1·04 (95% CI 0·94, 1·16) and 0·97 (95% CI 0·88, 1·07), respectively. In conclusion, the present data did not show an association among erythrocyte SDA, ALA or marine n-3 fatty acids and the risk of CHD in male physicians.
Authors:
Chisa Matsumoto; Nirupa R Matthan; Jemma B Wilk; Alice H Lichtenstein; J Michael Gaziano; Luc Djoussé
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-26
Journal Detail:
Title:  The British journal of nutrition     Volume:  109     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-17     Completed Date:  2013-07-29     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  2044-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging
Aspirin / administration & dosage,  pharmacology*
Case-Control Studies
Coronary Disease / prevention & control*
Double-Blind Method
Erythrocytes / chemistry,  metabolism*
Fatty Acids, Omega-3 / blood,  chemistry,  metabolism*
Humans
Macular Degeneration / prevention & control
Male
Middle Aged
Neoplasms / prevention & control
Risk Factors
Vitamins / pharmacology
beta Carotene / administration & dosage,  pharmacology*
Grant Support
ID/Acronym/Agency:
CA-097193/CA/NCI NIH HHS; CA-34944/CA/NCI NIH HHS; CA-40360/CA/NCI NIH HHS; HL-26490/HL/NHLBI NIH HHS; HL-34595/HL/NHLBI NIH HHS; R01 CA034944-03/CA/NCI NIH HHS; R01 CA040360/CA/NCI NIH HHS; R01 CA097193/CA/NCI NIH HHS; R01 HL026490-03/HL/NHLBI NIH HHS; R01 HL034595-07/HL/NHLBI NIH HHS; R21 HL088081/HL/NHLBI NIH HHS; R21 HL088081/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Vitamins; 01YAE03M7J/beta Carotene; P4CEK3495O/stearidonic acid; R16CO5Y76E/Aspirin
Comments/Corrections

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