Document Detail

Erythrocyte sodium transport and the probability of having hypertension.
MedLine Citation:
PMID:  8818921     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A number of alterations of ion transport and concentrations have been reported in erythrocytes from patients with hypertension and their young normotensive offspring. Of these, only sodium-lithium countertransport appears to be capable of predicting the effects of genetic variation on interindividual differences in blood pressure. OBJECTIVE: As a first step toward identifying other erythrocyte traits capable of predicting the effects of genetic variation on interindividual differences in blood pressure, we evaluated whether furosemide-sensitive sodium or potassium cotransport, ouabain-sensitive sodium pump, passive permeability to sodium or potassium, or intracellular concentrations of sodium or potassium are predictors of the probability of having hypertension in a general Caucasian population; we also attempted to confirm our previous inference that sodium-lithium countertransport is a predictor of the probability of having hypertension in this population. METHODS: The sample for analyses consisted of 199 unrelated men, aged 56-91 years, and 216 unrelated, nonpregnant women, aged 53-87 years, from the population of Rochester, Minnesota. Logistic regression was used to assess the relationship between predictor traits and blood pressure diagnostic status (normotension or hypertension). We assessed whether each erythrocyte trait was a predictor of the probability of having hypertension when the trait was considered by itself and when it was considered after the effects of other identified predictors of the probability of hypertension were included in the logistic regression models. RESULTS: When each erythrocyte trait was considered by itself, the predictors of the probability of having hypertension were sodium-lithium countertransport in men and sodium-lithium countertransport, sodium and potassium cotransport, and intracellular sodium concentration in women. When each erythrocyte trait was considered after other predictors had been included in the logistic regression models, none of the erythrocyte traits made an additional contribution to prediction of the probability of having hypertension unless its interactions with other predictors were also included in the models. CONCLUSIONS: Multiple measures of erythrocyte ion transport are associated with hypertension in the general Caucasian population; however, most of these associations are context-dependent inasmuch as they are gender-specific and dependent on levels of other predictor traits.
S T Turner; C F Sing
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of hypertension     Volume:  14     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1997-01-16     Completed Date:  1997-01-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  829-37     Citation Subset:  IM    
Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
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MeSH Terms
Aged, 80 and over
Biological Markers / analysis
Erythrocytes / metabolism*
Evaluation Studies as Topic
Hypertension / blood*
Ion Transport*
Lithium / metabolism
Logistic Models
Middle Aged
Potassium / metabolism
Potassium Channels / physiology
Sex Factors
Sodium / blood*
Sodium Channels / physiology
Sodium-Potassium-Exchanging ATPase / physiology
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Potassium Channels; 0/Sodium Channels; 7439-93-2/Lithium; 7440-09-7/Potassium; 7440-23-5/Sodium; EC ATPase

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