| Erythrocyte sodium-lithium countertransport activity is inversely correlated to adiponectin, retinol binding protein 4 and body height. | |
| | |
MedLine Citation:
|
PMID: 20849357 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: We have previously described that the sodium/lithium countertransport (SLC) in the erythrocyte cell membrane is closely linked to obesity and insulin resistance. Adiponectin and retinol-binding protein 4 (RBP-4) are believed to affect obesity and insulin resistance. In the present study, we aimed to further characterize the relationship between SLC, inflammatory markers, adiponectin and RBP-4. METHODS: We included 93 clinically healthy 58-year-old men selected to display variations in insulin sensitivity. High sensitivity C-reactive protein (hs-CRP), TNF-alpha, soluble TNF-alpha-receptors (sTNFR) 1 and 2, IL-6 and RBP-4 were measured using antibody-based techniques. Adiponectin was determined by a radioimmunoassay kit. The lithium concentration in the special flux medium was measured by atomic absorption spectrophotometry. RESULTS: In univariate analyses, SLC correlated negatively with RBP-4 (r(s) = -0.256, p = -0.017) and to adiponectin (r(s) = -0.316, p = 0.003) and positively with TNF-alpha (r(s) = 0.346, p = 0.001) and hs-CRP (r(s) = 0.288, p = 0.005). There were no statistically significant correlations with sTNFR 1 or 2 or IL-6. SLC was negatively associated to body height (r(s) = -0.256, p = 0.013). CONCLUSIONS: We are the first to report that SLC correlates negatively with adiponectin and RBP-4. This finding is intriguing, as adiponectin is anti-inflammatory and anti-diabetic whereas RBP-4 supposedly decreases insulin sensitivity. We also observed a negative association between SLC activity and body height indicating that SLC activity is not primarily influenced by fat mass. The positive association of SLC with markers of inflammatory activity such as TNF-alpha and hs-CRP is in line with the proposed link between inflammation and insulin resistance. |
| | |
Authors:
|
Erik Elias; Ville Wallenius; Hans Herlitz; Göran M L Bergström; Fredrik J Olson; Carl J Behre |
Related Documents
:
|
9400917 - Plasma leptin in non-diabetic asian indians: association with abdominal adiposity. 17617917 - Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic sau... 17542037 - The relationship between nitric oxide and leptin in the lung of rat with streptozotocin... 10864587 - Increases in serum leptin levels during peritoneal dialysis are associated with inflamm... 6848467 - Insulin reverses hypertension and hypothalamic depression in streptozotocin diabetic rats. 14988277 - Scrutiny of the glutamine-fructose-6-phosphate transaminase 1 (gfpt1) locus reveals con... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-20 |
Journal Detail:
|
Title: Scandinavian journal of clinical and laboratory investigation Volume: 70 ISSN: 1502-7686 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: England |
Other Details:
|
Languages: eng Pagination: 487-91 Citation Subset: IM |
Affiliation:
|
Department of Gastrosurgical Research, Sahlgrenska Academy at the University of Gothenburg, Sweden. erik.elias@gu.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Factors affecting the difference between morning and evening home blood pressure: the Finn-Home stud...
Next Document: Mean platelet volume is increased in patients with severe obstructive sleep apnea.