Document Detail

Erythrocyte sodium content and transport in borderline and mild hypertension.
MedLine Citation:
PMID:  2456419     Owner:  NLM     Status:  MEDLINE    
Sodium content and transport of red blood cells were examined in 98 male blood donors. Regarding their blood pressure they were classified into the following groups: (a) 57 normotensives, (RR less than 140/90 mm Hg); (b) 24 borderline hypertensives (140/90 less than or equal to RR less than 160/95 mm Hg); and (c) 17 hypertensives (RR greater than 160/100 mm Hg). Compared with the normotensives the borderline hypertensives have significantly reduced red cell sodium content. The ouabain-resistant net Na+ uptake and the relative Na+ uptake, as a measure of the Na+/K+ pump, were significantly increased. With rising blood pressures the measured values turn to normal, so that no difference exists between the normotensive and hypertensive groups. It is supposed that in the initial or even prehypertensive state a considerable enhancement of the pump activity occurs, simultaneously accompanied by less marked increases in sodium influx, leading to a reduced intracellular sodium content. In the course of hypertension, possibly caused by the formation of a pump inhibitor, the sodium content of red cells turns to normal or supernormal values.
I Engelhardt; J Scholze
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Klinische Wochenschrift     Volume:  66     ISSN:  0023-2173     ISO Abbreviation:  Klin. Wochenschr.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-09-01     Completed Date:  1988-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985205R     Medline TA:  Klin Wochenschr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  447-50     Citation Subset:  IM    
Bereich Medizin (Charité) der Humboldt-Universität zu Berlin, Klinik für Innere Medizin.
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MeSH Terms
Blood Pressure
Erythrocytes / metabolism*
Hypertension / blood*
Ion Channels / metabolism
Middle Aged
Sodium / blood*
Reg. No./Substance:
0/Ion Channels; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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