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Erythrocyte sialic acid content during aging in humans: correlation with markers of oxidative stress.
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MedLine Citation:
PMID:  22377734     Owner:  NLM     Status:  MEDLINE    
Sialic acids are substituted neuraminic acid derivatives which are typically found at the outermost end of glycan chains on the membrane in all cell types. The role of erythrocyte membrane sialic acids during aging has been established however the relationship between sialic acid and oxidative stress is not fully understood. The present work was undertaken to analyze the relationship between erythrocyte membrane sialic acid with its plasma level, membrane and plasma lipid hydroperoxide levels and plasma total antioxidant capacity. Results show that sialic acid content decreases significantly (P< 0.001) in RBC membrane (r= -0.901) and increases in plasma (r=0.860) as a function of age in humans. Lipid peroxidation measured in the form of hydroperoxides increases significantly (P<0.001) in plasma (r=0.830) and RBC membranes (r=0.875) with age in humans. The Trolox Equivalent Total Antioxidant Capacity (TETAC) of plasma was found to be significantly decreased (P< 0.001, r=-0.844). We observe significant correlations between decrease of erythrocyte membrane sialic acid and plasma lipid hydroperoxide and TETAC. Based on the observed correlations, we hypothesize that increase in oxidative stress during aging may influence the sialic acid decomposition from membrane thereby altering the membrane configuration affecting many enzymatic and transporter activities. Considering the importance of plasma sialic acid as a diagnostic parameter, it is important to establish age-dependent reference.
Mohammad Murtaza Mehdi; Prabhakar Singh; Syed Ibrahim Rizvi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Disease markers     Volume:  32     ISSN:  1875-8630     ISO Abbreviation:  Dis. Markers     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-01     Completed Date:  2012-06-15     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  179-86     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Aging / blood*
Antioxidants / analysis
Biological Markers / blood*
Erythrocyte Membrane / chemistry*
Lipid Peroxidation
Lipid Peroxides / blood
Middle Aged
Oxidative Stress
Sialic Acids / blood*
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Lipid Peroxides; 0/Sialic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2012 Hindawi Publishing Corporation.
Received Day: 23 Month: 2 Year: 2012
Accepted Day: 23 Month: 2 Year: 2012
Print publication date: Year: 2012
Electronic publication date: Day: 29 Month: 2 Year: 2012
Volume: 32 Issue: 3
First Page: 179 Last Page: 186
PubMed Id: 22377734
ID: 3826584
Article Id: 293429
DOI: 10.3233/DMA-2011-0871

Erythrocyte Sialic Acid Content during Aging in Humans: Correlation with Markers of Oxidative Stress
Mohammad Murtaza MehdiI1
Prabhakar SinghI1
Syed Ibrahim RizviI1*
Department of BiochemistryUniversity of AllahabadAllahabadIndia
Correspondence: *Syed Ibrahim Rizvi:

Article Categories:
  • Other

Keywords: Erythrocyte, aging, sialic acid, oxidative stress.

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