Document Detail

Erythrocyte-sedimentation rate before and after in-vitro defibrination: A rapid and simple method for increasing its specificity.
MedLine Citation:
PMID:  74728     Owner:  NLM     Status:  MEDLINE    
The erythrocyte-sedimentation rate (E.S.R.) was measured before and after in-vitro defibrination in 107 patients with high E.S.R.S. The reduction in E.S.R. on defibrination correlates with the fibrinogen level while the post-defibrination E.S.R. correlates with the globulin level. The ratio between the post-defibrination E.S.R. and the pre-defibrination, or standard, E.S.R. varies with different diseases; it is highest when an excess of globulins is the cause of the high E.S.R. and lowest when there is an excess of fibrinogen. Measurement of the post-fibrination E.S.R. is quick and easy and may help in the initial investigation of a high E.S.R.
G Holdstock; J R Mitchell
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:    1977 Dec 24-31
Date Detail:
Created Date:  1978-03-21     Completed Date:  1978-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1314-6     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Protein Disorders / blood
Blood Sedimentation / methods*
Collagen Diseases / blood
Fibrinogen / analysis
Infection / blood
Multiple Myeloma / blood
Myocardial Infarction / blood
Neoplasms / blood
Serum Albumin / analysis
Serum Globulins / analysis
Reg. No./Substance:
0/Serum Albumin; 0/Serum Globulins; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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