Document Detail

Erythrocyte osmotic fragility in hypertension and during diuretic therapy.
MedLine Citation:
PMID:  10593154     Owner:  NLM     Status:  MEDLINE    
To determine the effect of diuretic therapy on osmotic fragility of red blood cells of hypertensive patients, 25 hypertensive and 15 normotensive subjects were followed up for 12 weeks. Osmotic fragility of erythrocytes of the hypertensive subjects were determined before treatment and at 6 weeks and 12 weeks after the start of diuretic therapy. The red cell size was larger in hypertensive subjects than in normal controls. With treatment, however, the red cell size was similar in the two groups of subjects. Osmotic fragility was higher in hypertensive subjects than in normotensive subjects. The osmotic fragility also became similar in the two groups with control of blood pressure in the hypertensive group. Osmotic fragility of red blood cells may be determined as a screening tool for hypertensive patients who will benefit from diuretic therapy.
A A Fasanmade
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  West African journal of medicine     Volume:  18     ISSN:  0189-160X     ISO Abbreviation:  West Afr J Med     Publication Date:    1999 Jul-Sep
Date Detail:
Created Date:  2000-01-03     Completed Date:  2000-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8301891     Medline TA:  West Afr J Med     Country:  NIGERIA    
Other Details:
Languages:  eng     Pagination:  183-6     Citation Subset:  IM    
Department of Physiology, College of Medicine, University of Ibadan, Nigeria.
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MeSH Terms
Case-Control Studies
Diuretics / adverse effects*
Erythrocyte Indices*
Hypertension / blood*,  drug therapy*,  etiology
Mass Screening / methods
Middle Aged
Osmotic Fragility*
Patient Selection
Reg. No./Substance:

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