Document Detail

Erythrocyte morphology and haemoglobin types of neonatal roan antelopes (Hippotragus equinus) with hypochromic poikilocytic anaemia.
MedLine Citation:
PMID:  16542675     Owner:  NLM     Status:  MEDLINE    
Neonatal, poikilocytic anaemia in some members of the Hippotragini has previously been documented but not fully investigated. This study was undertaken to describe the erythrocyte morphology of roan antelopes (Hippotragus equinus) during the first 4 weeks after birth and to identify aspects of haemoglobin (Hb) production that might be implicated in this syndrome. Twenty-nine roan antelope calves were sampled on, or close to, 1, 7, 14 and 28 days after birth. Erythrocyte morphology was characterized, and microhaematocrit values and Hb parameters determined, for each sampling occasion. Findings indicated a significant change in erythrocyte morphology during the neonatal period and two haemoglobin types, fetal and adult, were identified. The perinatal onset of adult Hb synthesis was delayed relative to the termination of fetal Hb production, resulting in the observed anaemia. Haemoglobin concentration and erythrocyte morphology were significantly correlated. These findings suggest an intimate relationship between Hb synthesis and the observed poikilocytosis. An imbalance in the synthesis of the alpha- and beta-globin chains of Hb (a thalassaemia) may prove to be the underlying pathophysiology of this syndrome.
S D C Parsons; B L Penzhorn; F Reyers; J C A Steyl; P J Becker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-20
Journal Detail:
Title:  Journal of comparative pathology     Volume:  134     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:    2006 Feb-Apr
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  152-60     Citation Subset:  IM    
Veterinary Wildlife Unit, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, 0110 South Africa.
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MeSH Terms
Anemia, Hemolytic, Congenital / blood,  pathology,  veterinary*
Anemia, Hypochromic / blood,  pathology,  veterinary*
Animal Diseases / pathology
Animals, Newborn
Antelopes / blood*
Chromatography, High Pressure Liquid / veterinary
Electrophoresis / veterinary
Erythrocyte Indices / veterinary
Erythrocytes, Abnormal / pathology*
Fetal Hemoglobin / analysis*
Reg. No./Substance:
9034-63-3/Fetal Hemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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