| Erythrocyte morphology and haemoglobin types of neonatal roan antelopes (Hippotragus equinus) with hypochromic poikilocytic anaemia. | |
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MedLine Citation:
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PMID: 16542675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonatal, poikilocytic anaemia in some members of the Hippotragini has previously been documented but not fully investigated. This study was undertaken to describe the erythrocyte morphology of roan antelopes (Hippotragus equinus) during the first 4 weeks after birth and to identify aspects of haemoglobin (Hb) production that might be implicated in this syndrome. Twenty-nine roan antelope calves were sampled on, or close to, 1, 7, 14 and 28 days after birth. Erythrocyte morphology was characterized, and microhaematocrit values and Hb parameters determined, for each sampling occasion. Findings indicated a significant change in erythrocyte morphology during the neonatal period and two haemoglobin types, fetal and adult, were identified. The perinatal onset of adult Hb synthesis was delayed relative to the termination of fetal Hb production, resulting in the observed anaemia. Haemoglobin concentration and erythrocyte morphology were significantly correlated. These findings suggest an intimate relationship between Hb synthesis and the observed poikilocytosis. An imbalance in the synthesis of the alpha- and beta-globin chains of Hb (a thalassaemia) may prove to be the underlying pathophysiology of this syndrome. |
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Authors:
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S D C Parsons; B L Penzhorn; F Reyers; J C A Steyl; P J Becker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-20 |
Journal Detail:
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Title: Journal of comparative pathology Volume: 134 ISSN: 0021-9975 ISO Abbreviation: J. Comp. Pathol. Publication Date: 2006 Feb-Apr |
Date Detail:
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Created Date: 2006-04-17 Completed Date: 2006-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0102444 Medline TA: J Comp Pathol Country: England |
Other Details:
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Languages: eng Pagination: 152-60 Citation Subset: IM |
Affiliation:
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Veterinary Wildlife Unit, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, 0110 South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Hemolytic, Congenital
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blood,
pathology,
veterinary* Anemia, Hypochromic / blood, pathology, veterinary* Animal Diseases / pathology Animals Animals, Newborn Antelopes / blood* Chromatography, High Pressure Liquid / veterinary Electrophoresis / veterinary Erythrocyte Indices / veterinary Erythrocytes, Abnormal / pathology* Fetal Hemoglobin / analysis* |
| Chemical | |
Reg. No./Substance:
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9034-63-3/Fetal Hemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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