| Erythrocyte membrane phospholipid composition as a biomarker of dietary fat. | |
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MedLine Citation:
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PMID: 16373991 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: In a cross-sectional study, we investigated the relationship between erythrocyte membrane phospholipid fatty acid composition and dietary fat; we also investigated roles of menopausal status, age, body mass index (BMI) and waist-to-hip ratio (WHR) in interindividual variation of the biomarker. METHODS: Study participants were 204 women, aged 39-65 years, drawn from the ORDET cohort and selected as controls in a study of breast cancer. Membrane composition was assessed using capillary gas chromatography. Dietary fat composition was evaluated using a food frequency questionnaire. RESULTS: In pre- and postmenopausal women, erythrocyte membrane phospholipid levels of linoleic acid, oleic acid, and mono-unsaturated fatty acids were significantly associated with corresponding dietary measures (partial correlation coefficients: 0.23 and 0.39; 0.45 and 0.47; 0.40 and 0.48; respectively, in pre- and postmenopausal women). Among postmenopausal women, membrane poly-unsaturated fatty acids were correlated with the corresponding dietary measure (r=0.39, p<0.001). Membrane eicosapentanoic and docosahexanoic acid levels were significantly correlated with intake of fish/shell fish : r=0.21 and r=0.43 (premenopausal), and r=0.41 and r=0.44 (postmenopausal). Age, BMI and WHR had independent effects on membrane lipid composition. Age was associated with delta-6 desaturase activity in postmenopausal women (r=0.25, p<0.05). BMI was negatively associated with delta-9 desaturase activity in both pre- and postmenopausal women (r=-0.29, p=0.01 and r=-0.22, p<0.01, respectively). WHR was negatively associated with delta-5 desaturase activity in pre-menopausal women (r=-024, p<0.05). CONCLUSIONS: Erythrocyte membrane levels of some specific fatty acids can be used as biomarkers of these fatty acids as proportions of dietary fat. |
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Authors:
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Barbara J Fuhrman; Maddalena Barba; Vittorio Krogh; Andrea Micheli; Valeria Pala; Rossella Lauria; Veronique Chajes; Elio Riboli; Sabina Sieri; Franco Berrino; Paola Muti |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-12-21 |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 50 ISSN: 0250-6807 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-03-01 Completed Date: 2006-06-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: Switzerland |
Other Details:
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Languages: eng Pagination: 95-102 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2006 S. Karger AG, Basel. |
Affiliation:
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Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, NY 14214, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Biological Markers / analysis Body Mass Index Chromatography, Gas / methods Cohort Studies Cross-Sectional Studies Dietary Fats / metabolism* Dietary Fats, Unsaturated / metabolism* Erythrocyte Membrane / chemistry* Fatty Acid Desaturases / metabolism Fatty Acids / analysis Fatty Acids, Unsaturated / analysis Female Humans Menopause* / metabolism Middle Aged Phospholipids / analysis*, chemistry Questionnaires Waist-Hip Ratio |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Dietary Fats; 0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Phospholipids; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.99.-/delta-5 fatty acid desaturase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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