| Erythrocyte membrane microviscosity and blood pressure in rats with salt-induced and spontaneous hypertension. | |
| | |
MedLine Citation:
|
PMID: 8021475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To study membrane viscosity in various rat strains with genetic forms of experimental hypertension. DESIGN: The relationship between blood pressure and membrane dynamics was investigated in erythrocytes from three different rat strains with experimental hypertension, namely two models of salt-induced hypertension (Sabra and Dahl rats) and Lyon hypertensive rats with spontaneous hypertension. METHODS: Membrane microviscosity was evaluated by diphenylhexatriene and trimethylamino-diphenylhexatriene fluorescence steady-state anisotropy. RESULTS: There were no significant differences among particular experimental groups in trimethylamino-diphenylhexatriene anisotropy that reflect microviscosity changes at the water-lipid interface of the external membrane leaflet. In contrast, the diphenylhexatriene anisotropy, which is related to the core membrane microviscosity, was significantly reduced in the Dahl salt-sensitive rats (irrespective of salt intake level) and in the Sabra hypertension-prone rats with developed salt hypertension. Erythrocyte membranes of Lyon hypertensive rats also had lower values of diphenylhexatriene anisotropy than the respective normotensive controls but this difference was not statistically significant. CONCLUSIONS: Systolic (and often also diastolic) blood pressure correlated negatively with the diphenylhexatriene anisotropy in each of the three strains studied, whereas the trimethylamino-diphenylhexatriene anisotropy of the erythrocyte membranes had no significant relationship to the blood pressure. Further experiments should clarify whether the observed relationship of the diphenylhexatriene anisotropy to blood pressure reflects true pathogenetic mechanisms or is a consequence of haemodynamic changes. |
| | |
Authors:
|
J Kunes; J Zicha; M A Devynck |
Related Documents
:
|
8266005 - Water immersion and salt-sensitivity in essential hypertension. 19485915 - Protective effect of dietary potassium against cardiovascular damage in salt-sensitive ... 8820325 - A modified trigg's tracking variable as an 'advisory' alarm during anaesthesia. 15955745 - Vascular endothelin in hypertension. 19920695 - Effects of topical k-strophanthin on aqueous humor and corneal dynamics. 8035635 - Severe asthma complicated by bilateral diaphragmatic paralysis attributed to parsonage-... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of hypertension Volume: 12 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1994 Mar |
Date Detail:
|
Created Date: 1994-07-29 Completed Date: 1994-07-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 229-34 Citation Subset: IM |
Affiliation:
|
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / physiology* Diphenylhexatriene / analogs & derivatives Disease Models, Animal Erythrocyte Membrane / physiology* Fluorescence Polarization Fluorescent Dyes Hypertension / blood*, etiology, genetics Male Membrane Fluidity / physiology* Rats Rats, Inbred Strains Sodium Chloride / toxicity Viscosity |
| Chemical | |
Reg. No./Substance:
|
0/Fluorescent Dyes; 1720-32-7/Diphenylhexatriene; 71316-28-4/1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol leve...
Next Document: Renal interleukin-6 production in normotensive and hypertensive rats.