Document Detail

Erythrocyte membrane microviscosity and blood pressure in rats with salt-induced and spontaneous hypertension.
MedLine Citation:
PMID:  8021475     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study membrane viscosity in various rat strains with genetic forms of experimental hypertension. DESIGN: The relationship between blood pressure and membrane dynamics was investigated in erythrocytes from three different rat strains with experimental hypertension, namely two models of salt-induced hypertension (Sabra and Dahl rats) and Lyon hypertensive rats with spontaneous hypertension. METHODS: Membrane microviscosity was evaluated by diphenylhexatriene and trimethylamino-diphenylhexatriene fluorescence steady-state anisotropy. RESULTS: There were no significant differences among particular experimental groups in trimethylamino-diphenylhexatriene anisotropy that reflect microviscosity changes at the water-lipid interface of the external membrane leaflet. In contrast, the diphenylhexatriene anisotropy, which is related to the core membrane microviscosity, was significantly reduced in the Dahl salt-sensitive rats (irrespective of salt intake level) and in the Sabra hypertension-prone rats with developed salt hypertension. Erythrocyte membranes of Lyon hypertensive rats also had lower values of diphenylhexatriene anisotropy than the respective normotensive controls but this difference was not statistically significant. CONCLUSIONS: Systolic (and often also diastolic) blood pressure correlated negatively with the diphenylhexatriene anisotropy in each of the three strains studied, whereas the trimethylamino-diphenylhexatriene anisotropy of the erythrocyte membranes had no significant relationship to the blood pressure. Further experiments should clarify whether the observed relationship of the diphenylhexatriene anisotropy to blood pressure reflects true pathogenetic mechanisms or is a consequence of haemodynamic changes.
J Kunes; J Zicha; M A Devynck
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  12     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-29     Completed Date:  1994-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  229-34     Citation Subset:  IM    
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
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MeSH Terms
Blood Pressure / physiology*
Diphenylhexatriene / analogs & derivatives
Disease Models, Animal
Erythrocyte Membrane / physiology*
Fluorescence Polarization
Fluorescent Dyes
Hypertension / blood*,  etiology,  genetics
Membrane Fluidity / physiology*
Rats, Inbred Strains
Sodium Chloride / toxicity
Reg. No./Substance:
0/Fluorescent Dyes; 1720-32-7/Diphenylhexatriene; 71316-28-4/1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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