| Erythrocyte membrane fatty acids in patients with multiple sclerosis. | |
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MedLine Citation:
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PMID: 19435752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Reports on fatty acids levels in multiple sclerosis remain inconclusive. OBJECTIVE: To determine the erythrocyte membrane fatty acid levels in multiple sclerosis patients and correlate with Kurtzke Expanded Disability Status Scale. METHODS: Fatty acid composition of 31 multiple sclerosis and 30 control individuals were measured by gas chromatography. RESULTS: The membrane phosphatidylcholine C20:4n - 6 concentration was lower in the multiple sclerosis patients when compared to that of the control group, P = 0.04 and it correlated inversely with the EDSS and FSS. CONCLUSION: Decrease in C20:4n - 6 in the erythrocyte membrane could be an indication of depleted plasma stores, and a reflection of disease severity. |
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Authors:
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G M Hon; M S Hassan; S J van Rensburg; S Abel; D W Marais; P van Jaarsveld; C M Smuts; F Henning; R T Erasmus; T Matsha |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-12 |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 15 ISSN: 1352-4585 ISO Abbreviation: Mult. Scler. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2009-08-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: England |
Other Details:
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Languages: eng Pagination: 759-62 Citation Subset: IM |
Affiliation:
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Department of Bio-Medical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, P O Box 1906, Bellville 7530, Cape Town, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, Gas Disability Evaluation* Erythrocyte Membrane / metabolism* Fatty Acids / metabolism* Female Humans Multiple Sclerosis, Chronic Progressive / metabolism* Multiple Sclerosis, Relapsing-Remitting / metabolism* Phosphatidylcholines / metabolism Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Phosphatidylcholines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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