Document Detail

Erythrocyte membrane fatty acid content in infants consuming formulas supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA): an observational study.
MedLine Citation:
PMID:  21050388     Owner:  NLM     Status:  MEDLINE    
In this observational study, we compared erythrocyte membrane fatty acids in infants consuming formula supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA) with those consuming other types of milks. In 110 infants who were participants in a cohort study of otherwise healthy children at risk for developing type 1 diabetes, erythrocytes were collected at approximately 9 months of age, and fatty acid content was measured as a percentage of total lipids. Parents reported the type of milk the infants consumed in the month of and prior to erythrocyte collection: infant formula supplemented with ARA and DHA (supplemented formula), formula with no ARA and DHA supplements (non-supplemented formula), breast milk, or non-supplemented formula plus breast milk. Membrane DHA (4.42 versus 1.79, P < 0.001) and omega-3 fatty acid (5.81 versus 3.43, P < 0.001) levels were higher in infants consuming supplemented versus non-supplemented formula. Omega-6 fatty acids were lower in infants consuming supplemented versus non-supplemented formula (26.32 versus 29.68, P = 0.023); ARA did not differ between groups. Infants given supplemented formula had higher DHA (4.42 versus 2.81, P < 0.001) and omega-3 fatty acids (5.81 versus 4.45, P = 0.008) than infants drinking breast milk. In infants whose mothers did not receive any dietary advice, use of supplemented formula is associated with higher omega-3 and lower omega-6 fatty acid status.
Melissa R Miller; Jennifer Seifert; Nancy J Szabo; Michael Clare-Salzler; Marian Rewers; Jill M Norris
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Maternal & child nutrition     Volume:  6     ISSN:  1740-8709     ISO Abbreviation:  Matern Child Nutr     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2011-02-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101201025     Medline TA:  Matern Child Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  338-46     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado 80045, USA.
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MeSH Terms
Arachidonic Acid / administration & dosage*,  analysis,  blood
Breast Feeding*
Cohort Studies
Docosahexaenoic Acids / administration & dosage*,  analysis,  blood
Erythrocyte Membrane / chemistry*
Fatty Acids, Omega-3 / analysis,  blood
Fatty Acids, Omega-6 / analysis,  blood
Food, Fortified*
Infant Formula / chemistry*
Milk, Human
Grant Support
P30 DK 57516/DK/NIDDK NIH HHS; R01 DK032493-12/DK/NIDDK NIH HHS; R01 DK032493-29/DK/NIDDK NIH HHS; R01 DK049654-03/DK/NIDDK NIH HHS; R01 DK049654-14/DK/NIDDK NIH HHS; R01-DK32493/DK/NIDDK NIH HHS; R01-DK49654/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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