Document Detail


Erythrocyte membrane fatty acid composition, serum lipids, and non-Hodgkin's lymphoma risk in a nested case-control study: the multiethnic cohort.
MedLine Citation:
PMID:  22907421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Composition of dietary fatty acid intake, which influences cytokine production, may contribute to the development of non-Hodgkin's lymphoma (NHL). Serum lipid levels may serve as biomarkers of inflammation associated with NHL risk.
METHODS: We conducted a case-control analysis (275 cases and 549 controls) nested within the Multiethnic Cohort Study (whites, Japanese Americans, Latinos, African Americans, and Native Hawaiians) to examine the association of prediagnostic, erythrocyte membrane phospholipid fatty acid composition, and serum cholesterol and triglyceride (TG) concentrations with the risk of NHL. Conditional logistic regression was used to calculate odds ratios (OR) and 95 % confidence intervals (CI) by tertiles of biomarker concentrations.
RESULTS: Higher total saturated fatty acids (SFA) were associated with an increase in NHL risk (OR(T3 vs. T1) = 1.57 [95 % CI: 1.03-2.39]; p(trend) = 0.01), whereas no associations were detected for total n-3 or n-6 polyunsaturated fatty acids. Inverse associations were observed for total cholesterol (TC; OR (T3 vs. T1) = 0.51 [95 % CI: 0.35-0.74]; p(trend) < 0.0001) and high-density lipoprotein cholesterol (HDL-C; OR (T3 vs. T1) = 0.47 [95 % CI: 0.31-0.71]; p(trend) = 0.0001) but not for low-density lipoprotein cholesterol or TG. Adjustment for the use of lipid-lowering medication did not modify the results substantially.
CONCLUSIONS: This prospective biomarker investigation offers supportive evidence for an adverse effect of higher erythrocyte membrane SFA levels on NHL risk, but preclinical effects cannot be excluded. Inverse relations between prediagnostic, circulating TC and HDL-C and NHL risk may be due to reverse causation or a result of protective actions of these lipids and lipoproteins.
Authors:
Yukiko Morimoto; Shannon M Conroy; Nicholas J Ollberding; Susanne M Henning; Adrian A Franke; Lynne R Wilkens; Marc T Goodman; Brenda Y Hernandez; Loïc Le Marchand; Brian E Henderson; Laurence N Kolonel; Gertraud Maskarinec
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-21
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  23     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-17     Completed Date:  2013-08-28     Revised Date:  2014-06-06    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1693-703     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
African Americans
Aged
Biological Markers / blood
Case-Control Studies
Cholesterol / blood
Cholesterol, HDL / blood
Cohort Studies
Confidence Intervals
Erythrocyte Membrane / chemistry*
European Continental Ancestry Group
Fatty Acids / blood*
Female
Humans
Lipids / blood
Logistic Models
Lymphoma, Non-Hodgkin / epidemiology,  ethnology*,  metabolism*
Male
Prospective Studies
Risk
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
N01 PC 35137/PC/NCI NIH HHS; N01 PC 35139/PC/NCI NIH HHS; N01 PC035137/PC/NCI NIH HHS; P01 CA 033619/CA/NCI NIH HHS; P01 CA033619/CA/NCI NIH HHS; P30 CA071789/CA/NCI NIH HHS; P30 CA71789/CA/NCI NIH HHS; R25 CA 90956/CA/NCI NIH HHS; R25 CA090956/CA/NCI NIH HHS; R37 CA 54281/CA/NCI NIH HHS; R37 CA054281/CA/NCI NIH HHS; U01 CA 63464/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, HDL; 0/Fatty Acids; 0/Lipids; 0/Triglycerides; 97C5T2UQ7J/Cholesterol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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