Document Detail


Erythrocyte membrane enzymes in sickle cell anemia. 2. Acetylcholinesterase and ATPase activities.
MedLine Citation:
PMID:  2149641     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activity level of acetylcholinesterase in the erythrocytes of 32 patients homozygous for sickle cell anemia was determined and compared with that of normal AA controls as well as with that of AS individuals. Acetylcholinesterase activity was markedly higher in erythrocyte membrane from SS individuals than in those from AS individuals or AA controls. Additionally, ATPase activities were also significantly higher in sickle cell erythrocytes as compared to normal cells. These higher values of acetylcholinesterase and ATPase activities in SS erythrocytes may be explained as a consequence of the abnormally high cation levels in sickle cell erythrocytes.
Authors:
E O Eluwa; O Obidoa; A U Ogan; H A Onwubiko
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical medicine and metabolic biology     Volume:  44     ISSN:  0885-4505     ISO Abbreviation:  Biochem. Med. Metab. Biol.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-04-01     Completed Date:  1991-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8605718     Medline TA:  Biochem Med Metab Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  234-7     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Nigeria, Nsukka, Anambra State.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / blood*
Adenosine Triphosphatases / blood*
Anemia, Sickle Cell / blood,  enzymology*
Cations, Divalent / blood
Erythrocyte Membrane / enzymology*
Humans
Sickle Cell Trait / enzymology
Chemical
Reg. No./Substance:
0/Cations, Divalent; EC 3.1.1.7/Acetylcholinesterase; EC 3.6.1.-/Adenosine Triphosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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