Document Detail

Erythrocyte mean corpuscular volume associated with the anatomical distribution in peripheral arterial disease.
MedLine Citation:
PMID:  12099149     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Elevated erythrocyte mean corpuscular volume (MCV) has been suggested to be a risk factor for peripheral arterial disease (PAD). The aim of the present study was to evaluate whether MCV was associated with a distinct pattern of severe atherosclerosis (lumen reductions > or = 75%) in patients with symptomatic PAD, as measured by angiography.
PATIENTS AND METHODS: 100 consecutively admitted male PAD patients with iliac, femoral-popliteal and crural disease manifestation were compared with 100 male age-matched control subjects without PAD on the basis of angiographically determined lumen reductions > or = 75%.
RESULTS: The pattern of severe atherosclerosis was as follows: 41 PAD patients displayed stenoses/occlusions in the iliac segment, 68 in the femoral-popliteal and 15 in the crural segment. When comparing the PAD patients with the controls by multivariate conditional logistic regression analysis, MCV was an independent predictor of severe atherosclerosis in the iliac (OR = 2.72 for an increment of 5 fl, 95% CI = 1.15-6.40) and the femoral-popliteal segment (OR = 3.13 for an increment of 5 fl, 95% CI = 1.51-6.49) but not in the crural site. This pattern was similar to the impact of smoking.
CONCLUSION: Higher MCV values contributed to lumen reductions > or = 75% of the proximal segments in patients with symptomatic PAD. This observation could be clinically important since revascularisation procedures are done predominantly in these segments. As a consequence, observance of elevated MCV values should be considered in PAD patients.
T Mueller; C Luft; D Haidinger; W Poelz; M Haltmayer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  VASA. Zeitschrift für Gefässkrankheiten     Volume:  31     ISSN:  0301-1526     ISO Abbreviation:  VASA     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-07-08     Completed Date:  2002-09-03     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0317051     Medline TA:  Vasa     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  81-5     Citation Subset:  IM    
Department of Laboratory Medicine, University of Linz, Austria.
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MeSH Terms
Aged, 80 and over
Arterial Occlusive Diseases / blood*,  radiography
Arteriosclerosis / blood*,  radiography
Erythrocyte Indices*
Ischemia / blood,  radiography
Leg / blood supply
Middle Aged
Risk Factors

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