Document Detail


Erythrocyte ion regulation across inactive muscle during leg exercise.
MedLine Citation:
PMID:  1301241     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ion concentration changes in whole blood, plasma, and erythrocytes across inactive muscle were examined in eight healthy males performing four 30-s bouts of maximal isokinetic cycling with 4 min rest between each bout. Blood was sampled from the arm brachial artery and deep antecubital vein during the intermittent exercise period and for 90 min of recovery. Arterial and venous erythrocyte lactate concentration ([Lac-]) increased from 0.3 +/- 0.1 to 12.5 +/- 1.3 (p < 0.01) and 1.1 +/- 0.4 to 8.5 +/- 1.5 mmol/L (p < 0.01), respectively, returning to control values during recovery. Arterial and venous plasma [Lac-] increased from 1.5 +/- 0.2 to 27.7 +/- 1.8 and from 1.3 +/- 0.4 to 25.7 +/- 3.5 mmol/L, respectively, and was greater than erythrocyte [Lac-] throughout exercise and recovery. Arterial and venous [K+] increased in erythrocytes from 119.5 +/- 5.1 to 125.4 +/- 4.6 (p < 0.01) and from 113.6 +/- 1.7 to 120.6 +/- 7.1 mmol/L, respectively, decreasing to control during recovery. In arterial and venous plasma, [K+] increased from 4.3 +/- 0.1 to 6.1 +/- 0.2 (p < 0.01) and from 4.5 +/- 0.2 to 5.3 +/- 0.2 mmol/L (p < 0.01), respectively, decreasing to control during recovery. The efflux of Lac- out of erythrocytes against an electrochemical concentration gradient suggests the presence of an active transport system. Efflux of K+ from erythrocytes as blood passes across inactive muscle affords an important adaptation to the K+ release from muscle activated in heavy exercise.
Authors:
R S McKelvie; M I Lindinger; N L Jones; G J Heigenhauser
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  70     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-06-03     Completed Date:  1993-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1625-33     Citation Subset:  IM; S    
Affiliation:
Hamilton General Hospital, Ont., Canada.
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium
Adult
Chlorides / metabolism
Erythrocytes / metabolism*
Exercise / physiology*
Hematocrit
Hemoglobins / metabolism
Humans
Lactates / metabolism
Leg / physiology
Male
Muscles / metabolism*
Plasma Volume / physiology
Potassium / metabolism
Rest
Sodium / metabolism
Chemical
Reg. No./Substance:
0/Chlorides; 0/Hemoglobins; 0/Lactates; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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