Document Detail


Erythrocyte insulin binding in preterm newborn infants.
MedLine Citation:
PMID:  3517797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To characterize the erythrocyte insulin receptor in newborn infants we studied the binding of 125I-insulin to the erythrocytes from 42 preterm infants (14 at birth, 14 aged 2-7 days, and 14 aged 8-16 days) with a mean gestational age of 34.1 wk, and from 32 term infants (16 at birth and 16 aged 2-7 days). The insulin binding to cord blood erythrocytes from preterm infants was significantly higher than that of cord blood cells from term infants and to postnatal cells from preterm as well as term infants. The erythrocytes from preterm infants aged 2-7 days bound more insulin than cells from preterm infants aged 8-16 days. The maximum insulin binding (specific insulin binding at tracer concentration of insulin) correlated negatively with the gestational age both at birth and over the 1st postnatal wk. In the preterm infants there was a strong negative correlation between the maximum insulin binding and postnatal age. The enhanced insulin binding to cord blood erythrocytes from preterm infants was due to both an increased receptor concentration and a high affinity for insulin. The increased affinity persisted over the 1st wk of life. In preterm infants older than 1 wk the insulin binding characteristics were basically similar to those in term newborn infants. In all infants studied the receptor concentration seemed to be postnatal age dependent while the receptor affinity was gestational age dependent. No correlation was found between the insulin binding data and the plasma concentrations of immunoreactive insulin or C-peptide.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
R Puukka; M Knip; P Lautala; L Perkkilä; M Puukka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  20     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-05-28     Completed Date:  1986-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  256-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Glucose / analysis
C-Peptide / analysis
Erythrocytes / metabolism*
Female
Fetal Blood
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Insulin / blood*
Male
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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