Document Detail


Erythrocyte glucose-6-phosphate dehydrogenase isoenzyme phenotypes in leprosy.
MedLine Citation:
PMID:  6683258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemolysates from 50 cases of leprosy and five controls were studied for glucose-6-phosphate dehydrogenase (G-6-PD) isoenzyme phenotypes by polyacrylamide disc gel electrophoresis using a miniaturized system. The cases were classified as lepromatous (24), borderline lepromatous (5), borderline tuberculoid (5), and tuberculoid (16) according to the Ridley-Jopling scale. All had been on treatment with dapsone for between two and 12 years. None of the cases showed deficiency of erythrocyte G-6-PD. All the cases and the controls showed the G-6-PD phenotype to be of the B+ variety. Therefore this genetic marker does not appear to be related to susceptibility to leprosy or to the clinical variety of the disease in our situation.
Authors:
A M Saoji; S S Kelkar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association     Volume:  51     ISSN:  0148-916X     ISO Abbreviation:  Int. J. Lepr. Other Mycobact. Dis.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8505819     Medline TA:  Int J Lepr Other Mycobact Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Erythrocytes / enzymology
Glucosephosphate Dehydrogenase / genetics*
Glucosephosphate Dehydrogenase Deficiency / genetics
Humans
Isoenzymes / genetics*
Leprosy / enzymology*,  genetics
Phenotype
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 1.1.1.49/Glucosephosphate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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