Document Detail


Erythrocyte deformability changes in headache patients under flunarizine treatment.
MedLine Citation:
PMID:  4016927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Changes in erythrocyte deformability (ED) parameters have been investigated in 36 patients suffering from different forms of headache (classic and common migraine; migraine with interval headache; chronic tension headache) and treated with flunarizine (10 mg/day at bedtime). Patients were carefully selected in order to avoid any possible interference with the parameters under study, and smoke and drug use in particular (symptomatics included) were considered as criteria for exclusion from the trial. Controls of ED parameters were planned before treatment and after 20 and 35 days. Baseline ED alterations were present only among patients with chronic tension headache, but flunarizine treatment was able to positively modify ED parameters in these patients, as well as in migraine cases that showed normal baseline ED values. No correlation was found between patients' characteristics and baseline ED values, nor between ED changes under treatment and therapeutic effects of flunarizine.
Authors:
V Covelli; G Polimeno; M A Savarese; F Antonaci; F M Puca; A Tannoia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  5 Suppl 2     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-09-16     Completed Date:  1985-09-16     Revised Date:  2008-02-11    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  159-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Calcium Channel Blockers / therapeutic use*
Cinnarizine / analogs & derivatives,  therapeutic use*
Erythrocyte Deformability / drug effects*
Female
Flunarizine
Headache / blood,  prevention & control*
Humans
Male
Middle Aged
Migraine Disorders / blood,  prevention & control
Piperazines / therapeutic use*
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Piperazines; 298-57-7/Cinnarizine; 52468-60-7/Flunarizine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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