Document Detail


Erythrocyte autoantibodies, autoimmune haemolysis and pregnancy.
MedLine Citation:
PMID:  6814064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical and serological records of 20 pregnant patients with erythrocyte autoantibodies were critically reviewed and analysed. This series, the largest reported, confirmed an association between erythrocyte autosensitization and pregnancy, and suggested that this occurred on an average of 1 in 50,000 pregnancies. The clinical presentation varied from severe haemolytic anaemia to serological abnormalities discovered during the routine testing of well patients; overt haemolysis was present in 7 cases. Treatment was only necessary in 3 patients where the haemolysis was severe. 3 infants were mildly affected with haemolytic disease due to the maternal autoantibodies crossing the placenta but no treatment was needed. The risks to the infant were increased when other active autoimmune conditions (e.g., systemic lupus erythematosus) were present. With early diagnosis and appropriate treatment, outlook for mother and child is good.
Authors:
R J Sokol; S Hewitt; B K Stamps
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Vox sanguinis     Volume:  43     ISSN:  0042-9007     ISO Abbreviation:  Vox Sang.     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-21     Completed Date:  1982-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  169-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
ABO Blood-Group System / immunology*
Adult
Anemia, Hemolytic, Autoimmune / diagnosis,  etiology*
Autoantibodies / biosynthesis*
Blood Group Incompatibility / diagnosis
Coombs' Test
England
Female
Humans
Infant, Newborn
Pregnancy
Pregnancy Complications, Hematologic / diagnosis,  etiology,  immunology*
Rh-Hr Blood-Group System / immunology*
Chemical
Reg. No./Substance:
0/ABO Blood-Group System; 0/Autoantibodies; 0/Rh-Hr Blood-Group System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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