| Erythrocyte sedimentation rate and C-reactive protein for the prediction of severity of acute pancreatitis. | |
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MedLine Citation:
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PMID: 20531240 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate the performance of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) for predicting severe acute pancreatitis (AP). METHODS: Fifty patients with AP were prospectively enrolled. Erythrocyte sedimentation rate and CRP were measured at admission and every 12 hours for 48 hours after admission. RESULTS: The patients' mean age was 50 ± 2.2 years, 64% were male, and 30% developed severe AP. Patients with severe AP had higher levels of ESR (77 ± 4.7 vs 50 ± 4.8 mm/h; P = 0.002) and CRP (218 ± 30.7 vs 97 ± 12.1 mg/L; P <0.001) at 36 hours after admission compared with those with mild AP. Erythrocyte sedimentation rates of 60 mm/h or greater predict severe AP at 36 hours with a sensitivity, specificity, and positive and negative predictive values of 86%, 57%, and 48% and 90%, whereas CRP of 150 mg/L or greater provided the results of 86%, 87%, and 75% and 93%, respectively. Elevation of either ESR or CRP at 24 hours increased the sensitivity and negative predictive value to 100%, and elevation of both ESR and CRP increased the specificity and PPV to 100%. CONCLUSIONS: Erythrocyte sedimentation rate can predict severe AP with a slightly inferior performance to CRP. Combined ESR and CRP at 24 hours can predict severe AP accurately. |
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Authors:
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Supot Pongprasobchai; Voravut Jianjaroonwong; Phunchai Charatcharoenwitthaya; Chulaluk Komoltri; Tawesak Tanwandee; Somchai Leelakusolvong; Nonthalee Pausawasdi; Wichit Srikureja; Siwaporn Chainuvati; Varayu Prachayakul; Sathaporn Manatsathit; Udom Kachintorn |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pancreas Volume: 39 ISSN: 1536-4828 ISO Abbreviation: Pancreas Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States |
Other Details:
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Languages: eng Pagination: 1226-30 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Department of Internal Medicine, Siriraj Hospital, Bangkok, Thailand. tespb@mahidol.ac.th |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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