Document Detail

Erythrocyte sedimentation rate and C-reactive protein for the prediction of severity of acute pancreatitis.
MedLine Citation:
PMID:  20531240     Owner:  NLM     Status:  In-Process    
OBJECTIVES: To investigate the performance of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) for predicting severe acute pancreatitis (AP).
METHODS: Fifty patients with AP were prospectively enrolled. Erythrocyte sedimentation rate and CRP were measured at admission and every 12 hours for 48 hours after admission.
RESULTS: The patients' mean age was 50 ± 2.2 years, 64% were male, and 30% developed severe AP. Patients with severe AP had higher levels of ESR (77 ± 4.7 vs 50 ± 4.8 mm/h; P = 0.002) and CRP (218 ± 30.7 vs 97 ± 12.1 mg/L; P <0.001) at 36 hours after admission compared with those with mild AP. Erythrocyte sedimentation rates of 60 mm/h or greater predict severe AP at 36 hours with a sensitivity, specificity, and positive and negative predictive values of 86%, 57%, and 48% and 90%, whereas CRP of 150 mg/L or greater provided the results of 86%, 87%, and 75% and 93%, respectively. Elevation of either ESR or CRP at 24 hours increased the sensitivity and negative predictive value to 100%, and elevation of both ESR and CRP increased the specificity and PPV to 100%.
CONCLUSIONS: Erythrocyte sedimentation rate can predict severe AP with a slightly inferior performance to CRP. Combined ESR and CRP at 24 hours can predict severe AP accurately.
Supot Pongprasobchai; Voravut Jianjaroonwong; Phunchai Charatcharoenwitthaya; Chulaluk Komoltri; Tawesak Tanwandee; Somchai Leelakusolvong; Nonthalee Pausawasdi; Wichit Srikureja; Siwaporn Chainuvati; Varayu Prachayakul; Sathaporn Manatsathit; Udom Kachintorn
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  39     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1226-30     Citation Subset:  IM    
Division of Gastroenterology, Department of Internal Medicine, Siriraj Hospital, Bangkok, Thailand.
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