| Erythrocyte Na(+)-Li+ countertransport in essential hypertension: correlation with membrane lipids levels. | |
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MedLine Citation:
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PMID: 8884551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine whether Na(+)-Li+ countertransport (SLC) activity is linked to erythrocyte membrane lipid content. DESIGN: An observational case-control study. The maximal efflux rate of SLC, plasma cholesterol, triglycerides, phospholipids, low- and high-density lipoprotein cholesterol levels and the erythrocyte membrane cholesterol, phospholipids and fatty acids contents were determined both in fasting normolipaemic normotensive subjects and in hypertensive patients. METHODS: The Li(+)-stimulated Na+ efflux was measured in Li(+)-preloaded erythrocytes. Membrane cholesterol and phospholipids levels were determined by the latroscan technique. Membrane fatty acids were identificated by gas chromatography. Several derived indices were also obtained. RESULTS: Erythrocyte membranes of hypertensive patients showed an increase in cholesterol: phospholipid ratio and a decrease in the total amount of polyunsaturated fatty acids, mainly at the expense of arachidonic acid and docosatetraenoic acid. SLC activity was higher in hypertensive patients and correlated positively with the plasma triglycerides level and negatively with the ratio of C20:4 to C20:3. CONCLUSION: Our data from untreated normolipaemic hypertensive patients show that a higher SLC activity was accompanied by parameters that indicate a lower membrane fluidity. |
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Authors:
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J Villar; C Montilla; O Muñiz-Grijalvo; F G Muriana; P Stiefel; V Ruiz-Gutiérrez; J Carneado |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 14 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1997-01-23 Completed Date: 1997-01-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 969-73 Citation Subset: IM |
Affiliation:
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Unidad de Hipertensión y Lipidos, Universitario Virgen del Rocio, Sevilla, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antiporters / analysis* Erythrocyte Membrane / chemistry* Erythrocytes / metabolism* Female Humans Hypertension / metabolism* Lithium / metabolism* Male Membrane Lipids / analysis* Regression Analysis Sodium / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antiporters; 0/Membrane Lipids; 0/sodium-lithium countertransporter; 7439-93-2/Lithium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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