Document Detail


Erythrocyte 2,3-diphosphoglycerate, PO250%, and available oxygen in young rabbits with and without postnatal fall in hemoglobin.
MedLine Citation:
PMID:  6701045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined erythrocyte 2,3-diphosphoglycerate (2,3-DPG), PO250%, whole blood hemoglobin concentration, and available O2 from the 12th to the 30th d after birth in two matched groups of young rabbits. One group received iron parenterally on the 12th, 15th, and 18th d and the other received no iron supplement. In the untreated group there was a marked fall in hemoglobin concentration from the 12th to the 22nd d and thereafter a marked increase to the initial level on the 30th d whereas the iron-treated animals showed a marked rise in hemoglobin concentration from the 12th to the 22nd d, and a subsequent, slight decline from the 22nd to the 30th d. The average values of PO250% and 2,3-DPG, and the changes in PO250% and 2,3-DPG were virtually identical for both groups. During the first period (12-22 d) there was a marked rise in both 2,3-DPG and PO250% whereas in the second period (22-30 d) there was a somewhat smaller rise in 2,3-DPG and only a slight tendency toward a further rise in PO250%. In the untreated animals "available O2," reflecting the O2 delivery capacity of the blood, remained unchanged during the period of fall in hemoglobin concentration and showed a rise during the second period. In the iron-treated animals "available O2" rose markedly during the first period, with iron-treatment, and remained unchanged during the second period. We conclude that the marked postnatal rise in 2,3-DPG and PO250% in the rabbit seems to be independent of the changes in the hemoglobin concentration.
Authors:
P H Holter; S Halvorsen; H E Refsum
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  18     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-04-11     Completed Date:  1984-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  154-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
2,3-Diphosphoglycerate
Aging
Anemia, Hypochromic / blood,  prevention & control
Animals
Diphosphoglyceric Acids / blood*
Erythrocyte Indices
Erythrocytes / metabolism*
Hematocrit
Hemoglobins / metabolism*
Injections, Intramuscular
Iron / administration & dosage,  blood
Oxygen / blood*
Rabbits
Chemical
Reg. No./Substance:
0/Diphosphoglyceric Acids; 0/Hemoglobins; 138-81-8/2,3-Diphosphoglycerate; 7439-89-6/Iron; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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