Document Detail


Erythema multiforme and Stevens-Johnson syndrome. Descriptive and therapeutic controversy.
MedLine Citation:
PMID:  2198136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diagnosis and particularly the management of erythema multiforme and Stevens-Johnson syndrome are controversial in medical textbooks and thus in individual cases. In these diseases, fatalities may result from various causes, including secondary infection or visceral organ damage to lung, liver, or kidneys. We present a series of 13 cases managed by one group of physicians which demonstrates the controversy in certain cases, and we review the controversy in the medical literature. Corticosteroid therapy used in this series was considered beneficial in every case by the managing physician and lifesaving in some cases. There were no fatalities in this series. Although the summation may be considered as our opinion only, the frequently suggested "controlled trial of corticosteroid therapy" can probably never be done for ethical reasons, and series such as this will have to establish the standard of therapy.
Authors:
R Patterson; M S Dykewicz; A Gonzalzles; L C Grammer; D Green; P A Greenberger; K G McGrath; C L Walker
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Chest     Volume:  98     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-04     Completed Date:  1990-09-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  331-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Northwestern University Medical School, Chicago.
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MeSH Terms
Descriptor/Qualifier:
Epidermal Necrolysis, Toxic
Erythema Multiforme* / diagnosis,  drug therapy
Female
Humans
Hydrocortisone / therapeutic use
Middle Aged
Prednisone / therapeutic use
Stevens-Johnson Syndrome* / diagnosis,  drug therapy
Terminology as Topic*
Grant Support
ID/Acronym/Agency:
AI 11403/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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