Document Detail

Erythema induction by ultraviolet radiation points to a possible acquired defense mechanism in chronically sun-exposed human skin.
MedLine Citation:
PMID:  9031790     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is generally accepted that a UVA-induced erythema is difficult to detect except in the most sensitive individuals. OBJECTIVE AND METHODS: As UVA effects on human skin and skin cells have been shown to depend strongly on anatomical body sites, UVA I, UVA I + II and solar simulator radiations were compared in their ability to induce erythema and melanin pigmentation responses in individuals with skin types I-IV on both previously sun-exposed (arms, forearms, thighs) and nonexposed body sites (buttocks). RESULTS: Erythema induction by UVA I on previously nonexposed skin sites followed a dose response in all skin types which was contrary to the absence of erythema induction seen on previously sun-exposed sites. Melanin expression followed a dose and skin type response and was shown to be more enhanced in previously exposed skin and in skin types III and IV. In contrast, UVA I + II induced erythema on nonexposed skin areas and to a lesser extent on frequently sun-exposed skin. Melanin production by UVA I + II was similar to that seen with UVA I alone in individuals of skin types II and III. Solar simulator radiation was very efficient in erythema induction regardless of previous sun exposure of skin. CONCLUSIONS: We have found that contrary to the widespread opinion that UVA and in particular UVA I could not induce a significant erythema, this waveband is capable of measurable erythema induction on skin nonexposed to sunlight. The diminished erythema induction by UVA I on chronically sun-exposed skin suggests the possibility of a defense mechanism against UVA-induced damage in this tissue.
L A Applegate; C Scaletta; G Treina; R E Mascotto; A Fourtanier; E Frenk
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  194     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  1997  
Date Detail:
Created Date:  1997-04-29     Completed Date:  1997-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  41-9     Citation Subset:  IM    
Department of Dermatology, University Hospital, CHUV, Lausanne, Switzerland.
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MeSH Terms
Cells, Cultured
Dose-Response Relationship, Radiation
Erythema / etiology*
Melanins / radiation effects
Middle Aged
Skin / anatomy & histology,  cytology,  radiation effects*
Skin Pigmentation / radiation effects*
Sunlight / adverse effects*
Ultraviolet Rays / adverse effects*
Reg. No./Substance:

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