Document Detail


Erufosine, a novel alkylphosphocholine, induces apoptosis in CLL through a caspase-dependent pathway.
MedLine Citation:
PMID:  20092894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The alkylphosphocholine (APC) erufosine is a synthetic phospholipid analogue with antineoplastic activity. APC are known to interact with lipid metabolism and modulate cellular signaling pathways, particularly the phosphorylation of Akt. Here, in primary CLL cells induction of apoptosis was detected with an IC50 of 22muM whereas healthy donor PBMC were less sensitive towards erufosine. Treatment with erufosine caused dose-dependent cleavage of PARP, co-incubation with caspase inhibitor z-VAD almost completely abrogated the cytotoxic effect of erufosine indicating a caspase-dependent mechanism of erufosine. Erufosine was shown to induce apoptosis in primary CLL cells and merits further investigation regarding therapeutic options in CLL.
Authors:
Sonja Katharina K?nigs; Christian Philipp Pallasch; Lars Hartwin Lindner; Janine Schwamb; Alexandra Schulz; Reinhild Brinker; Julia Claasen; Aditya Veldurthy; Hansjoerg Eibl; Michael Hallek; Clemens-Martin Wendtner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-21
Journal Detail:
Title:  Leukemia research     Volume:  34     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1064-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Clinic I of Internal Medicine, University of Cologne, Cologne, Germany.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / drug effects*
Blotting, Western
Caspases / metabolism*
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*,  metabolism,  pathology
Phospholipases A2 / metabolism
Phosphoric Acid Esters / pharmacology*
Proto-Oncogene Proteins c-akt / metabolism
Quaternary Ammonium Compounds / pharmacology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Phosphoric Acid Esters; 0/Quaternary Ammonium Compounds; 0/erucylphospho-N,N,N-trimethylpropylammonium; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 3.1.1.4/Phospholipases A2; EC 3.4.22.-/Caspases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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